HIV/AIDS: in search of an animal model

被引：62

作者：

Ambrose, Zandrea

KewalRamani, Vineet N.

Bieniasz, Paul D.

Hatziioannou, Theodora ^{[1
]}

机构：

[1] Aaron Diamond AIDS Res Ctr, New York, NY 10016 USA

[2] Rockefeller Univ, New York, NY 10016 USA

[3] NCI, HIV Drug Resistance Program, Frederick, MD 21702 USA

来源：

TRENDS IN BIOTECHNOLOGY | 2007年 / 25卷 / 08期

关键词：

D O I：

10.1016/j.tibtech.2007.05.004

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

AIDS is among the most devastating diseases of our time, claiming the lives of approximately 3 million people per year. The primary cause of AIDS, human immunodeficiency virus type 1 (HIV-1), is a pathogen that is highly specific for humans and generally does not infect or cause disease in other species. This property complicates the generation of animal models that are urgently needed to test new antiretroviral therapies and vaccines. The most practical animal models developed to date consist of infection of rhesus macaques with a simian immunodeficiency virus (SIV) or chimeric HIV/SIV viruses. Although these models are useful for particular applications, the fact that SIV is a distinct virus compared with HIV-1 represents a significant limitation to their use. Here, we discuss the uses and limitations of existing models and recent advances that might lead to better animal models for HIV/AIDS.

引用

页码：333 / 337

页数：5

共 50 条

[1] REDUCED VIRUS LOAD IN RHESUS MACAQUES IMMUNIZED WITH RECOMBINANT GP160 AND CHALLENGED WITH SIMIAN IMMUNODEFICIENCY VIRUS [J].

AHMAD, S ;

LOHMAN, B ;

MARTHAS, M ;

GIAVEDONI, L ;

ELAMAD, Z ;

HAIGWOOD, NL ;

SCANDELLA, CJ ;

GARDNER, MB ;

LUCIW, PA ;

YILMA, T .

AIDS RESEARCH AND HUMAN RETROVIRUSES, 1994, 10 (02) :195-204

[2] Control of a mucosal challenge and prevention of AIDS by a multiprotein DNA/MVA vaccine [J].

Amara, RR ;

Villinger, F ;

Altman, JD ;

Lydy, SL ;

O'Neil, SP ;

Staprans, SI ;

Montefiori, DC ;

Xu, Y ;

Herndon, JG ;

Wyatt, LS ;

Candido, MA ;

Kozyr, NL ;

Earl, PL ;

Smith, JM ;

Ma, HL ;

Grimm, BD ;

Hulsey, ML ;

Miller, J ;

McClure, HM ;

McNicholl, JM ;

Moss, B ;

Robinson, HL .

SCIENCE, 2001, 292 (5514) :69-74

[3] In vitro characterization of a simian immunodeficiency virus-human immunodeficiency virus (HIV) chimera expressing HIV type 1 reverse transcriptase to study antiviral resistance in pigtail macaques [J].

Ambrose, Z ;

Boltz, V ;

Palmer, S ;

Coffin, JM ;

Hughes, SH ;

KewalRamani, VN .

JOURNAL OF VIROLOGY, 2004, 78 (24) :13553-13561

[4] Human neutralizing monoclonal antibodies of the IgG1 subtype protect against mucosal simian-human immunodeficiency virus infection [J].

Baba, TW ;

Liska, V ;

Hofmann-Lehmann, R ;

Vlasak, J ;

Xu, WD ;

Ayehunie, S ;

Cavacini, LA ;

Posner, MR ;

Katinger, H ;

Stiegler, G ;

Bernacky, BJ ;

Rizvi, TA ;

Schmidt, R ;

Hill, LR ;

Keeling, ME ;

Lu, YC ;

Wright, JE ;

Chou, TC ;

Ruprecht, RM .

NATURE MEDICINE, 2000, 6 (02) :200-206

[5] Disseminated and sustained HIV infection in CD34+ cord blood cell-transplanted Rag2-/-γc-/- mice [J].

Baenziger, Stefan ;

Tussiwand, Roxane ;

Schlaepfer, Erika ;

Mazzucchelli, Luca ;

Heikenwalder, Mathias ;

Kurrer, Michael O. ;

Behnke, Silvia ;

Frey, Joachim ;

Oxenius, Annette ;

Joller, Helen ;

Aguzzi, Adriano ;

Manz, Markus G. ;

Speck, Roberto F. .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2006, 103 (43) :15951-15956

[6] Mucosal AIDS vaccine reduces disease and viral load in gut reservoir and blood after mucosal infection of macaques [J].

Belyakov, IM ;

Hel, Z ;

Kelsall, B ;

Kuznetsov, VA ;

Ahlers, JD ;

Nacsa, J ;

Watkins, DI ;

Allen, TM ;

Sette, A ;

Altman, J ;

Woodward, R ;

Markham, PD ;

Clements, JD ;

Franchini, G ;

Strober, W ;

Berzofsky, JA .

NATURE MEDICINE, 2001, 7 (12) :1320-1326

[7] INOCULATION OF BABOONS AND MACAQUES WITH SIMIAN IMMUNODEFICIENCY VIRUS MNE, A PRIMATE LENTIVIRUS CLOSELY RELATED TO HUMAN IMMUNODEFICIENCY VIRUS TYPE-2 [J].

BENVENISTE, RE ;

MORTON, WR ;

CLARK, EA ;

TSAI, CC ;

OCHS, HD ;

WARD, JM ;

KULLER, L ;

KNOTT, WB ;

HILL, RW ;

GALE, MJ ;

THOULESS, ME .

JOURNAL OF VIROLOGY, 1988, 62 (06) :2091-2101

[8] Intrinsic immunity: a front-line defense against viral attack [J].

Bieniasz, PD .

NATURE IMMUNOLOGY, 2004, 5 (11) :1109-1115

[9] Microbial translocation is a cause of systemic immune activation in chronic HIV infection [J].

Brenchley, Jason M. ;

Price, David A. ;

Schacker, Timothy W. ;

Asher, Tedi E. ;

Silvestri, Guido ;

Rao, Srinivas ;

Kazzaz, Zachary ;

Bornstein, Ethan ;

Lambotte, Olivier ;

Altmann, Daniel ;

Blazar, Bruce R. ;

Rodriguez, Benigno ;

Teixeira-Johnson, Leia ;

Landay, Alan ;

Martin, Jeffrey N. ;

Hecht, Frederick M. ;

Picker, Louis J. ;

Lederman, Michael M. ;

Deeks, Steven G. ;

Douek, Daniel C. .

NATURE MEDICINE, 2006, 12 (12) :1365-1371

[10] CD4+ T cell depletion during all stages of HIV disease occurs predominantly in the gastrointestinal tract [J].

Brenchley, JM ;

Schacker, TW ;

Ruff, LE ;

Price, DA ;

Taylor, JH ;

Beilman, GJ ;

Nguyen, PL ;

Khoruts, A ;

Larson, M ;

Haase, AT ;

Douek, DC .

JOURNAL OF EXPERIMENTAL MEDICINE, 2004, 200 (06) :749-759

← 1 2 3 4 5 →