Urinary modified nucleosides as tumor markers

被引：18

作者：

Dudley, E

Lemiere, F

Van Dongen, W

Esmans, E

El-Sharkawi, AMM

Games, DE

Brenton, AG

Newton, RP

机构：

[1] Univ Coll Swansea, Biochem Grp, Sch Biol Sci, Swansea SA2 5PP, W Glam, Wales

[2] Univ Antwerp, Dept Chem, B-2020 Antwerp, Belgium

[3] Singleton Hosp, Oncol Unit, Swansea SA2 8QA, W Glam, Wales

[4] Univ Coll Swansea, Mass Spectrometry Res Unit, Dept Chem, Swansea, W Glam, Wales

来源：

NUCLEOSIDES NUCLEOTIDES & NUCLEIC ACIDS | 2003年 / 22卷 / 5-8期

关键词：

urinary nucleosides; cancer; modified nucleosides; mass spectrometry;

D O I：

10.1081/NCN-120022719

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Extracts of urinary nucleosides have been sequentially purified and examined by mass spectrometric analysis. Seventeen modified nucleosides have been unequivocally identified and a further five provisionally identified. While several nucleosides were found only in a small number of extracts, the occurrence and levels of others were found to correlate with the tumour type and stage.

引用

页码：987 / 989

页数：3

共 4 条

[1]

Dudley E, 2000, RAPID COMMUN MASS SP, V14, P1200, DOI 10.1002/1097-0231(20000730)14:14<1200::AID-RCM10>3.0.CO

[2]

2-I

[3] Development of a purification procedure for the isolation of nucleosides from urine prior to mass spectrometric analysis [J].