Expressing the human genome

被引：285

作者：

Tupler, R

Perini, G

Green, MR

机构：

[1] Univ Massachusetts, Sch Med, Howard Hughes Med Inst, Program Gene Funct, Worcester, MA 01605 USA

[2] Univ Massachusetts, Sch Med, Howard Hughes Med Inst, Program Express, Worcester, MA 01605 USA

[3] Univ Massachusetts, Sch Med, Howard Hughes Med Inst, Program Mol Med, Worcester, MA 01605 USA

[4] Univ Pavia, I-27100 Pavia, Italy

[5] Univ Bologna, Dipartimento Biol Evoluz & Sperimentale, I-40126 Bologna, Italy

来源：

NATURE | 2001年 / 409卷 / 6822期

关键词：

D O I：

10.1038/35057011

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

We have searched the human genome for genes encoding new proteins that may be involved in three nuclear gene expression processes: transcription, pre-messenger RNA splicing and polyadenylation. A plethora of potential new factors are implicated by sequence in nuclear gene expression, revealing a substantial but selective increase in complexity compared with Drosophila melanogaster and Caenorhabditis elegans. Although the raw genomic information has limitations, its availability offers new experimental approaches for studying gene expression.

引用

页码：832 / 833

页数：2

共 15 条

[1] Genes encoding Drosophila melanogaster RNA polymerase II general transcription factors:: Diversity in TFIIA and TFIID components contributes to gene-specific transcriptional regulation [J].