Cutting edge commentary: Origins of B-1 cells

被引:74
作者
Wortis, HH
Berland, R
机构
[1] Tufts Univ, Sch Med, Dept Pathol, Boston, MA 02111 USA
[2] Sackler Sch Grad Biomed Sci, Program Immunol, Boston, MA 02111 USA
关键词
D O I
10.4049/jimmunol.166.4.2163
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
The origin of B-1a cells, a minority population of B cells that express CD5, are abundant in coelomic cavities, and often produce autoantibodies, has been the subject of study for many years. Accumulating evidence demonstrates that the hypothesis that only B cells arising in fetal or neonatal tissues have the-potential to become B-1a cells cannot be true. Rather, B cell receptor-mediated signaling initiated by ligation of autoantigen has now been shown to be required for induction of the B-1a phenotype, Furthermore, cells with a functional B-1a phenotype can be induced from adult precursors by appropriate Ag. At the same time, microenvironment-specific events may determine the likelihood that a given B cell, either adult or fetal derived, enters this pathway. CD5 expression and possibly localization to the peritoneum appear to provide some protection to autoreactive cells otherwise slated for elimination.
引用
收藏
页码:2163 / 2166
页数:4
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