Low permeabilities of apical membranes of barrier epithelia: What makes watertight membranes watertight?

被引：47

作者：

Zeidel, ML

机构：

来源：

AMERICAN JOURNAL OF PHYSIOLOGY-RENAL PHYSIOLOGY | 1996年 / 271卷 / 02期

关键词：

kidney epithelium; collecting duct; loop of Henle; membrane permeability; epithelial polarity; plasma membranes; CELL-MEMBRANE; CHOLESTEROL; TRANSPORT; BLADDER; FLUIDITY;

D O I：

10.1152/ajprenal.1996.271.2.F243

中图分类号：

Q4 [生理学];

学科分类号：

071003 ;

摘要：

Several epithelia, including those of collecting duct (in the absence of antidiuretic hormone), thick ascending limb of Henle, and mammalian bladder exhibit extremely low permeabilities for water, small nonelectrolytes like urea, and protons. This brief review describes how apical membrane structure might account for these low permeabilities by incorporating recent biophysical and molecular modeling results.

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页码：F243 / F245

页数：3

相关论文

共 29 条

[1] VISCOUS FINGERING OF HCL THROUGH GASTRIC MUCIN [J].

BHASKAR, KR ;

GARIK, P ;

TURNER, BS ;

BRADLEY, JD ;

BANSIL, R ;

STANLEY, HE ;

LAMONT, JT .

NATURE, 1992, 360 (6403) :458-461

[2] INTERACTION OF CHOLESTEROL WITH SPHINGOMYELIN IN MONOLAYERS AND VESICLES [J].

BITTMAN, R ;

KASIREDDY, CR ;

MATTJUS, P ;

SLOTTE, JP .

BIOCHEMISTRY, 1994, 33 (39) :11776-11781

[3] PERMEABILITY PROPERTIES OF THE MAMMALIAN BLADDER APICAL MEMBRANE [J].

CHANG, A ;

HAMMOND, TG ;

SUN, TT ;

ZEIDEL, ML .

AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY, 1994, 267 (05) :C1483-C1492

[4]

DEAMER DW, 1995, PERMEABILITY STABILI, P161

[5]

Finkelstein A., 1986, WATER MOVEMENT LIPID

[6] WATER AND NONELECTROLYTE PERMEABILITIES OF APICAL MEMBRANES OF TOAD URINARY-BLADDER GRANULAR CELLS [J].

GROSSMAN, EB ;

HARRIS, HW ;

STAR, RA ;

ZEIDEL, ML .

AMERICAN JOURNAL OF PHYSIOLOGY, 1992, 262 (05) :C1109-C1118

[7]

Haines T.H., 1995, PERMEABILITY STABILI, P123

[8] WATER TRANSPORT ACROSS BIOLOGICAL-MEMBRANES [J].

HAINES, TH .

FEBS LETTERS, 1994, 346 (01) :115-122

[9] CURRENT UNDERSTANDING OF THE CELLULAR BIOLOGY AND MOLECULAR-STRUCTURE OF THE ANTIDIURETIC HORMONE-STIMULATED WATER TRANSPORT PATHWAY [J].

HARRIS, HW ;

STRANGE, K ;

ZEIDEL, ML .

JOURNAL OF CLINICAL INVESTIGATION, 1991, 88 (01) :1-8

[10] TEMPERATURE-DEPENDENCE OF ADH-INDUCED WATER-FLOW AND INTRAMEMBRANOUS PARTICLE AGGREGATES IN TOAD BLADDER [J].

KACHADORIAN, WA ;

MULLER, J ;

RUDICH, SW ;

DISCALA, VA .

SCIENCE, 1979, 205 (4409) :910-913