Prevention of clinical and histological signs of proteolipid protein (PLP)-induced experimental allergic encephalomyelitis (EAE) in mice by the water-soluble carbon monoxide-releasing molecule (CORM)-A1

被引：64

作者：

Fagone, P. ^{[1
]}

Mangano, K. ^{[1
]}

Quattrocchi, C. ^{[1
]}

Motterlini, R. ^{[3
]}

Di Marco, R. ^{[4
]}

Magro, G. ^{[2
]}

Penacho, N. ^{[5
]}

Romao, C. C. ^{[5
,6
]}

Nicoletti, F. ^{[1
]}

机构：

[1] Univ Catania, Sch Med, Dept Biomed Sci, I-95124 Catania, Italy

[2] Univ Catania, Sect Anat Pathol, Dept GF Ingrassia, I-95124 Catania, Italy

[3] Italian Inst Technol, Genoa, Italy

[4] Univ Molise, Dept Hlth Sci, Campobasso, Italy

[5] Alfama Lda, Porto Salvo, Portugal

[6] Univ Nova Lisboa, Inst Tecnol Quim & Biol, Oeiras, Portugal

来源：

CLINICAL AND EXPERIMENTAL IMMUNOLOGY | 2011年 / 163卷 / 03期

关键词：

animal models; carbon monoxide-releasing molecules; CORM-A1; experimental allergic encephalomyelitis; SJL mice; EXPERIMENTAL AUTOIMMUNE ENCEPHALOMYELITIS; COLLAGEN-INDUCED ARTHRITIS; INDUCED LUNG INJURY; HEME OXYGENASE-1; OXIDATIVE STRESS; CO; INDUCTION; CORM-A1; DEXAMETHASONE; INFLAMMATION;

D O I：

10.1111/j.1365-2249.2010.04303.x

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

We have evaluated the effects of the carbon monoxide-releasing molecule CORM-A1 [Na-2(BH3CO2); ALF421] on the development of relapsing-remitting experimental allergic encephalomyelitis (EAE) in SJL mice, an established model of multiple sclerosis (MS). The data show that the prolonged prophylactic administration of CORM-A1 improves the clinical and histopathological signs of EAE, as shown by a reduced cumulative score, shorter duration and a lower cumulative incidence of the disease as well as milder inflammatory infiltrations of the spinal cords. This study suggests that the use of CORM-A1 might represent a novel therapeutic strategy for the treatment of multiple sclerosis.

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页码：368 / 374

页数：7

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