Determinants of HIV seroconversion among men who have sex with men living in a low HIV incidence population in the era of highly active antiretroviral therapies

被引：28

作者：

Lavoie, Elaine ^{[1
]}

Alary, Michel ^{[1
,2
,8
]}

Remis, Robert S. ^{[3
]}

Otis, Joanne ^{[4
]}

Vincelette, Jean ^{[5
]}

Turmel, Bruno ^{[8
]}

Lavoie, Rene

Masse, Benoit R. ^{[7
]}

Le Clerc, Roger ^{[6
]}

机构：

[1] Univ Quebec, Ctr Hosp, Unite Rech & Sante Populat, Quebec City, PQ G1S 4L8, Canada

[2] Univ Laval, Dept Social & Prevent Med, Quebec City, PQ G1K 7P4, Canada

[3] Univ Toronto, Dept Publ Hlth Sci, Toronto, ON, Canada

[4] Univ Quebec, Dept Sexol, Montreal, PQ H3C 3P8, Canada

[5] Univ Montreal, Hop St Luc, Ctr Hosp, Microbiol Serv, Montreal, PQ H3C 3J7, Canada

[6] COCQ Sida, Montreal, PQ, Canada

[7] Fred Hutchison Canc Inst, Seattle, WA USA

[8] Inst Natl Sante Publ Quebec, Quebec City, PQ, Canada

来源：

SEXUALLY TRANSMITTED DISEASES | 2008年 / 35卷 / 01期

关键词：

D O I：

10.1097/OLQ.0b013e31814fb113

中图分类号：

R51 [传染病];

学科分类号：

100401 ;

摘要：

Objective: To estimate human immunodeficiency virus (HIV) incidence and associated risk factors among men who have sex with men (MSM) participating in the Omega Cohort Study in Montreal, 1996-2003. Methods: Longitudinal study of 1587 MSM seronegative at baseline with >= 1 six-month follow-up visit. Multivariate Cox regression with time-dependent variables was used for data analysis. Results: HIV incidence was 0.62 per 100 person-years (95% confidence interval: 0.41-0.84). In multivariate analyses compared with subjects not reporting any anal sex with serodiscordant or casual partners, those reporting anal sex with such partners (all P values <0.05), whether consistently protected [hazard ratio (HR) = 3.4], or unprotected exclusively receptive (HR = 12.0), exclusively insertive (HR = 4.7), or both receptive and insertive (HR = 8.3), were at increased risk of seroconversion. Sexual behaviors with seroconcordant regular partners were not associated with seroconversion. Conclusion: These results observed in a cohort of MSM with low HIV incidence provide new insights regarding the debate about harm-reduction strategies to prevent sexual HIV transmission.

引用

页码：25 / 29

页数：5

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