A Cascade Annulation Based Convergent Approach to Racemic Tetrodotoxin

被引：22

作者：

Cagide-Fagin, Fernando ^{[1
]}

Alonso, Ricardo ^{[1
]}

机构：

[1] Univ Santiago, Dept Quim Organ, Santiago De Compostela 15782, Spain

来源：

EUROPEAN JOURNAL OF ORGANIC CHEMISTRY | 2010年 / 2010卷 / 35期

关键词：

Natural products; Annulation; Cyclitols; beta-(Hetero)aryl-alpha-nitro-alpha; beta-enals; 2,2-Dimethyl-1,3-dioxan-5-one; EFFICIENT TOTAL-SYNTHESIS; SODIUM-CHANNEL; STEREOSELECTIVE-SYNTHESIS; EN-ROUTE; (-)-TETRODOTOXIN; DERIVATIVES; TOXINS;

D O I：

10.1002/ejoc.201001159

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The synthetic power of the recently developed cascade annulations of beta-(hetero)aryl-alpha-nitro-alpha,beta-enals with the pyrrolidine-derived enamine of 2,2-dimethyl-1,3-dioxan-5-one is demonstrated by the first convergent route to (+/-)-tetrodotoxin.

引用

页码：6741 / 6747

页数：7

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