Genetic advances for studying Mycobacterium tuberculosis pathogenicity

被引:38
作者
Pelicic, V [1 ]
Reyrat, JM [1 ]
Gicquel, B [1 ]
机构
[1] Inst Pasteur, Unite Genet Mycobacterienne, F-75724 Paris 15, France
关键词
D O I
10.1046/j.1365-2958.1998.00807.x
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Tuberculosis remains the greatest cause of death worldwide because of a single pathogen. Despite its importance, the genetic basis of the pathogenicity of Mycobacterium tuberculosis remains poorly understood, mainly because the most productive investigative approach, molecular genetic analysis, has been severely hampered by a lack of efficient tools. However, significant advances, including the development of methods for inactivating genes and studying their expression with reporter genes, have been recently made. This progress may lead to opportunities for developing new vaccines and antituberculous drugs. The aim of this review is to examine the present state of the art in mycobacterial molecular genetics and pinpoint some expected or promising areas for future research.
引用
收藏
页码:413 / 420
页数:8
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