Role of chromatin modification in flowering-time control

被引：225

作者：

He, YH ^{[1
]}

Amasino, RM ^{[1
]}

机构：

[1] Univ Wisconsin, Dept Biochem, Madison, WI 53706 USA

来源：

TRENDS IN PLANT SCIENCE | 2005年 / 10卷 / 01期

基金：

美国国家科学基金会;

关键词：

D O I：

10.1016/j.tplants.2004.11.003

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

The regulation of the FLC locus provides a plant model of how chromatin-modifying systems have emerged as important components in the control of a major developmental switch, the transition to flowering. Genetic and molecular studies have revealed that three systems of FLC regulation (vernalization, FRI and the autonomous pathway) all influence the state of FLC chromatin. Histone H3 trimethylation at lysine 4 and histone acetylation are associated with active FLC expression, whereas histone deacetylation and histone H3 dimethylation at lysines 9 and 27 are involved in FLC repression. These chromatin modifications provide an additional level of regulation of gene expression beyond that of the transcription factors that recruit RNA polymerase to target genes.

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收藏

页码：30 / 35

页数：6

相关论文

共 57 条

[1] Regulation of flowering time by FVE, a retinoblastoma-associated protein [J].

Ausín, I ;

Alonso-Blanco, C ;

Jarillo, JA ;

Ruiz-García, L ;

Martínez-Zapater, JM .

NATURE GENETICS, 2004, 36 (02) :162-166

[2]

Bannister AJ, 2004, METHOD ENZYMOL, V376, P269

[3] Vernalization requires epigenetic silencing of FLC by histone methylation [J].

Bastow, R ;

Mylne, JS ;

Lister, C ;

Lippman, Z ;

Martienssen, RA ;

Dean, C .

NATURE, 2004, 427 (6970) :164-167

[4] The Arabidopsis thaliana genome contains at least 29 active genes encoding SET domain proteins that can be assigned to four evolutionarily conserved classes [J].

Baumbusch, LO ;

Thorstensen, T ;

Krauss, V ;

Fischer, A ;

Naumann, K ;

Assalkhou, R ;

Schulz, I ;

Reuter, G ;

Aalen, RB .

NUCLEIC ACIDS RESEARCH, 2001, 29 (21) :4319-4333

[5] RETRACTED: Histone methylation by the Drosophila epigenetic transcriptional regulator Ash1 (Retracted article. See vol. 521, pg. 110, 2015) [J].

Beisel, C ;

Imhof, A ;

Greene, J ;

Kremmer, E ;

Sauer, F .

NATURE, 2002, 419 (6909) :857-862

[6] Phenotypic analysis of Paf1/RNA polymerase II complex mutations reveals connections to cell cycle regulation, protein synthesis, and lipid and nucleic acid metabolism [J].

Betz, JL ;

Chang, M ;

Washburn, TM ;

Porter, SE ;

Mueller, CL ;

Jaehning, JA .

MOLECULAR GENETICS AND GENOMICS, 2002, 268 (02) :272-285

[7] Multiple pathways in the decision to flower: Enabling, promoting, and resetting [J].

Boss, PK ;

Bastow, RM ;

Mylne, JS ;

Dean, C .

PLANT CELL, 2004, 16 (SUPPL.) :S18-S31

[8] ASH1, a Drosophila trithorax group protein, is required for methylation of lysine 4 residues on histone H3 [J].

Byrd, KN ;

Shearn, A .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2003, 100 (20) :11535-11540

[9] Analysis of the molecular basis of flowering time variation in Arabidopsis accessions [J].

Gazzani, S ;

Gendall, AR ;

Lister, C ;

Dean, C .

PLANT PHYSIOLOGY, 2003, 132 (02) :1107-1114

[10] The VERNALIZATION 2 gene mediates the epigenetic regulation of vernalization in Arabidopsis [J].

Gendall, AR ;

Levy, YY ;

Wilson, A ;

Dean, C .

CELL, 2001, 107 (04) :525-535

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