Facile three-components, one-pot synthesis of pyrimido[4,5-d]pyrimidine-2,5-dione derivatives under microwave-assisted conditions

被引：41

作者：

Dabiri, Minoo ^{[1
]}

Arvin-Nezhad, Hamid ^{[1
]}

Khavasi, Hamid R. ^{[1
]}

Bazgir, Ayoob ^{[1
]}

机构：

[1] Shahid Beheshti Univ, Fac Sci, Dept Chem, Tehran 1983963113, Iran

来源：

JOURNAL OF HETEROCYCLIC CHEMISTRY | 2007年 / 44卷 / 05期

关键词：

D O I：

10.1002/jhet.5570440505

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Pyrimido [4,5 -d]pyrimidine-2,5 -dione derivatives have been synthesized in high yields in a novel, one-pot, and efficient process by condensation of 6-amino-3 -methyl-2-(methylthio)pyrimidin -4 (3 H) -one, aldehydes and urea under microwave-assisted conditions.

引用

页码：1009 / 1011

页数：3

共 32 条

[1] Multiple-component condensation strategies for combinatorial library synthesis [J].

Armstrong, RW ;

Combs, AP ;

Tempest, PA ;

Brown, SD ;

Keating, TA .

ACCOUNTS OF CHEMICAL RESEARCH, 1996, 29 (03) :123-131

[2]

Bazgir A, 2006, J CHEM RES-S, P1

[3]

BERNIER JL, 1977, EUR J MED CHEM, V12, P341

[4]

Brown D. J., 1984, Comprehensive Heterocyclic Chemistry, V1, P57

[5] Solid-phase synthesis of natural product-like macrocycles by a sequence of Ugi-4CR and SNAr-based cycloetherification [J].

Cristau, P ;

Vors, JP ;

Zhu, JP .

TETRAHEDRON LETTERS, 2003, 44 (30) :5575-5578

[6]

DECLERCQ E, 1987, J BIOL CHEM, V262, P14905

[7] INHIBITION OF FERROUS-INDUCED LIPID-PEROXIDATION BY PYRIMIDO-PYRIMIDINE DERIVATIVES IN HUMAN LIVER MEMBRANES [J].

DELACRUZ, JP ;

CARRASCO, T ;

ORTEGA, G ;

DELACUESTA, FS .

LIPIDS, 1992, 27 (03) :192-194

[8]

Dömling A, 2000, ANGEW CHEM INT EDIT, V39, P3168, DOI 10.1002/1521-3773(20000915)39:18<3168::AID-ANIE3168>3.0.CO

[9]

2-U

[10] Multicomponent Hantzsch cyclocondensation as a route to highly functionalized 2- and 4-dihydropyridylalanines, 2- and 4-pyridylalanines, and their N-oxides:: preparation via a polymer-assisted solution-phase approach [J].

Dondoni, A ;

Massi, A ;

Minghini, E ;

Bertolasi, V .

TETRAHEDRON, 2004, 60 (10) :2311-2326

← 1 2 3 4 →