Increased physical activity and the growth hormone IGF-I axis in adolescent males

被引:130
作者
Eliakim, A
Brasel, JA
Mohan, S
Wong, WLT
Cooper, DM
机构
[1] Univ Calif Irvine, Coll Med, Dept Pediat, Irvine, CA 92697 USA
[2] Harbor UCLA Med Ctr, Dept Pediat, Div Pediat Endocrinol, Torrance, CA 90509 USA
[3] Loma Linda Univ, Pettis Vet Affairs Med Ctr, Dept Med, Loma Linda, CA 92357 USA
[4] Loma Linda Univ, Pettis Vet Affairs Med Ctr, Dept Biochem, Loma Linda, CA 92357 USA
[5] Loma Linda Univ, Pettis Vet Affairs Med Ctr, Dept Physiol, Loma Linda, CA 92357 USA
[6] Genentech Inc, Dept Bioanalyt Technol, S San Francisco, CA 94080 USA
关键词
binding proteins; muscle volume; energy expenditure; magnetic resonance imaging; insulin-like growth factor-I;
D O I
10.1152/ajpregu.1998.275.1.R308
中图分类号
Q4 [生理学];
学科分类号
071003 ;
摘要
Insulin-like growth factor-I (IGF-I) is associated with muscle hypertrophy, and circulating IGF-I levels are correlated with fitness. To test the hypothesis that IGF-I increases with increased physical activity in adolescent males, 38 subjects (16 +/- 0.7 yr old) were randomized to control (n = 18) or increased physical activity groups for 5 wk. Before and after the intervention, we measured thigh muscle volume using magnetic resonance imaging and serum levels of mean growth hormone (GH) by overnight multiple sampling, GH binding protein (GHBP), IGF-I, and IGFBPs 1-5 by standard assays. Energy expenditure was assessed with the doubly labeled water technique toward the end of the study. In the training subjects there was 1) a significant increase in thigh muscle volume (+3.6 +/- 1%), 2) 15.5 +/- 3.3% greater energy expenditure than in controls, and 3) no evidence of weight loss (+1.44 +/- 0.4%). In contrast to our hypothesis, but similar to our recent observations in adolescent females, training decreased IGF-I (-12 +/- 4%, P < 0.005). Moreover, training substantially reduced GHBP (-21 +/- 4%, P < 0.00002) and increased IGFBP-2 (+40 +/- 16%, P < 0.008). Brief training increased muscle volume in weight-stable adolescent males and, surprisingly, influenced not only IGF-I but GHBP and IGFBP-2 as well in a manner typically found in energy-deficient states.
引用
收藏
页码:R308 / R314
页数:7
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