Do heat shock proteins control the balance of T-cell regulation in inflammatory diseases?

被引：129

作者：

van Eden, W

van der Zee, R

Paul, AGA

Prakken, BJ

Wendling, U

Anderton, SM

Wauben, MHM

机构：

[1] Univ Utrecht, Inst Infect Dis & Immunol, NL-3508 TD Utrecht, Netherlands

[2] Univ Hosp Children & Youth, Het Wilhelmina Kinderziekenhuis, NL-3512 LK Utrecht, Netherlands

[3] Univ Bristol, Sch Med, Dept Pathol & Microbiol, Bristol BS8 1TH, Avon, England

来源：

IMMUNOLOGY TODAY | 1998年 / 19卷 / 07期

关键词：

D O I：

10.1016/S0167-5699(98)01283-3

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Heat shock proteins (Hsps) are remarkably immunogenic, despite their high degree of evolutionary conservation. Experimental and clinical observations on autoimmune diseases indicate that immune responses to Hsps arise spontaneously during the disease process. Willem van Eden and colleagues argue that such immunity to Hsps is part of a normal immunoregulatory T-cell response with disease controlling potential.

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页码：303 / 307

页数：5

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