Survival signals in leukemic large granular lymphocytes

被引：38

作者：

Epling-Burnette, PK

Loughran, TP

机构：

[1] Univ S Florida, H Lee Moffit Canc Ctr & Res Inst, Hematol Malignancy Program, Tampa, FL 33612 USA

[2] James A Haley Vet Adm Med Ctr, Tampa, FL 33612 USA

来源：

SEMINARS IN HEMATOLOGY | 2003年 / 40卷 / 03期

关键词：

D O I：

10.1016/S0037-1963(03)00135-5

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

The central hypothesis of our laboratory research program in large granular lymphocyte (LGL) leukemia is that leukemic LGL represent antigen-driven cytotoxic T lymphocytes (CTL) with characteristics of dysregulated apoptosis. The clinical features of LGL leukemia highlight the association of autoimmune diseases such as rheumatoid arthritis with the T-cell form of LGL leukemia. We therefore used LGL leukemia as a model disease of dysregulated apoptosis leading to both malignant and autoimmune diseases. Here, we review our understanding of survival signals activated in leukemic LGL in the context of knowledge concerning apoptotic pathways in activated normal lymphocytes. © 2003 Elsevier Inc. All rights reserved.

引用

页码：213 / 220

页数：8

共 108 条

[1] The Bcl-2 protein family: Arbiters of cell survival [J].