The human DF3/MUC1 carcinoma-associated antigen signals nuclear localization of the catenin p120ctn

被引：54

作者：

Li, YQ ^{[1
]}

Kufe, D ^{[1
]}

机构：

[1] Harvard Univ, Sch Med, Dana Farber Canc Inst, Boston, MA 02115 USA

来源：

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 2001年 / 281卷 / 02期

关键词：

MUC1; cytoplasmic tail; p120(ctn); nuclear signals;

D O I：

10.1006/bbrc.2001.4383

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The human DF3/MUC1 glycoprotein is aberrantly overexpressed by carcinoma cells. The present studies show that MUC1 associates with the Armadillo protein, p120(ctn). The cytoplasmic domain of MUC1 binds directly to p120, The functional significance of the MUC1-p120 association is supported by the demonstration that MUC1 induces nuclear localization of p120, These findings demonstrate that MUC1 confers cell membrane to nuclear signaling by interactions with p120, (C) 2001 Academic Press

引用

页码：440 / 443

页数：4

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