Molecular diversity of pacemaker ion channels

被引：277

作者：

Kaupp, UB ^{[1
]}

Seifert, R ^{[1
]}

机构：

[1] Forschungszentrum Julich, Inst Biol Informat Verarbeitung, D-52425 Julich, Germany

来源：

ANNUAL REVIEW OF PHYSIOLOGY | 2001年 / 63卷

关键词：

hyperpolarization-activated current; pacemaker current; HCN channels; cyclic nucleotides;

D O I：

10.1146/annurev.physiol.63.1.235

中图分类号：

Q4 [生理学];

学科分类号：

071003 ;

摘要：

Ionic currents activated by hyperpolarization and regulated by cyclic nucleotides were first discovered more than 20 years ago. Recently the molecular identity of the underlying channels has been unveiled. The structural features of the protein sequences are discussed and related to the mechanisms of activation, selectivity for cyclic nucleotides, and ion permeation. Coverage includes a comparison of the biophysical properties of recombinant and native channels and their significance for the physiological functions of these channels.

引用

页码：235 / 257

页数：23

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