The crystallographic model of rhodopsin and its use in studies of other G protein-coupled receptors

被引:94
作者
Filipek, S [1 ]
Teller, DC
Palczewski, K
Stenkamp, R
机构
[1] Univ Washington, Dept Biol Struct, Seattle, WA 98195 USA
[2] Univ Washington, Dept Biochem, Seattle, WA 98195 USA
[3] Univ Washington, Dept Ophthalmol, Seattle, WA 98195 USA
[4] Univ Washington, Dept Chem, Seattle, WA 98195 USA
[5] Univ Washington, Dept Pharmacol, Seattle, WA 98195 USA
[6] Univ Washington, Biomol Struct Ctr, Seattle, WA 98195 USA
[7] Warsaw Univ, Int Inst Mol & Cell Biol, PL-02109 Warsaw, Poland
[8] Warsaw Univ, Fac Chem, PL-02109 Warsaw, Poland
来源
ANNUAL REVIEW OF BIOPHYSICS AND BIOMOLECULAR STRUCTURE | 2003年 / 32卷
关键词
transmembrane protein; signal transduction; homology models; vision; phototransduction;
D O I
10.1146/annurev.biophys.32.110601.142520
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
G protein-coupled receptors (GPCRs) are integral membrane proteins that respond to environmental signals and initiate signal transduction pathways activating cellular processes. Rhodopsin is a GPCR found in rod cells in retina where it functions as a photopigment. Its molecular structure is known from cryo-electron microscopic and X-ray crystallographic studies, and this has reshaped many structure/function questions important in vision science. In addition, this first GPCR structure has provided a structural template for studies of other GPCRs, including many known drug targets. After presenting an overview of the major structural elements of rhodopsin, recent literature covering the use of the rhodopsin structure in analyzing other GPCRs will be summarized. Use of the rhodopsin structural model to understand the structure and function of other GPCRs provides strong evidence validating the structural model.
引用
收藏
页码:375 / 397
页数:27
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