Neurobiology - Snails, synapses and smokers

被引：36

作者：

Dougherty, DA

Lester, HA

机构：

[1] CALTECH, Div Chem & Chem Engn, Pasadena, CA 91125 USA

[2] CALTECH, Div Biol, Pasadena, CA 91125 USA

来源：

NATURE | 2001年 / 411卷 / 6835期

关键词：

D O I：

10.1038/35077192

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

The discovery of a protein that controls the transmission of nerve impulses in snails is significant in its own right. It also advances our understanding of the vertebrate neurotransmitter receptor that responds to nicotine.

引用

页码：252 / 254

页数：4

共 13 条

[1] Crystal structure of an ACh-binding protein reveals the ligand-binding domain of nicotinic receptors [J].

Brejc, K ;

van Dijk, WJ ;

Klaassen, RV ;

Schuurmans, M ;

van der Oost, J ;

Smit, AB ;

Sixma, TK .

NATURE, 2001, 411 (6835) :269-276

[2] Nicotinic receptors at the amino acid level [J].

Corringer, PJ ;

Le Novère, N ;

Changeux, JP .

ANNUAL REVIEW OF PHARMACOLOGY AND TOXICOLOGY, 2000, 40 :431-458

[3] ACETYLCHOLINE BINDING BY A SYNTHETIC RECEPTOR - IMPLICATIONS FOR BIOLOGICAL RECOGNITION [J].

DOUGHERTY, DA ;

STAUFFER, DA .

SCIENCE, 1990, 250 (4987) :1558-1560

[4] MOLECULAR DECOYS - LIGAND-BINDING RECOMBINANT PROTEINS PROTECT MICE FROM CURARIMIMETIC NEUROTOXINS [J].

GERSHONI, JM ;

ARONHEIM, A .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1988, 85 (11) :4087-4089

[5]

KAO PN, 1984, J BIOL CHEM, V259, P1662

[6] EFFECTS OF BLOCKING SULFHYDRYL GROUPS AND OF REDUCING DISULFIDE BONDS ON ACETYLCHOLINE-ACTIVATED PERMEABILITY SYSTEM OF ELECTROPLAX [J].

KARLIN, A ;

BARTELS, E .

BIOCHIMICA ET BIOPHYSICA ACTA, 1966, 126 (03) :525-&

[7] Listening to neurotransmitter transporters [J].

Lester, HA ;

Cao, YW ;

Mager, S .

NEURON, 1996, 17 (05) :807-810

[8] Nicotinic acetylcholine receptor at 4.6 Å resolution:: Transverse tunnels in the channel wall [J].

Miyazawa, A ;

Fujiyoshi, Y ;

Stowell, M ;

Unwin, N .

JOURNAL OF MOLECULAR BIOLOGY, 1999, 288 (04) :765-786

[9]

OLEARY ME, 1992, J BIOL CHEM, V267, P8360

[10] D-TUBOCURARINE BINDING-SITES ARE LOCATED AT ALPHA-GAMMA AND ALPHA-DELTA SUBUNIT INTERFACES OF THE NICOTINIC ACETYLCHOLINE-RECEPTOR [J].

PEDERSEN, SE ;

COHEN, JB .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1990, 87 (07) :2785-2789

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