Potential therapeutic uses of BDNF in neurological and psychiatric disorders

被引：743

作者：

Nagahara, Alan H. ^{[1
]}

Tuszynski, Mark H. ^{[1
,2
]}

机构：

[1] Univ Calif San Diego, Dept Neurosci 0626, Ctr Neural Repair, La Jolla, CA 92093 USA

[2] Vet Adm Med Ctr, San Diego, CA 92161 USA

来源：

NATURE REVIEWS DRUG DISCOVERY | 2011年 / 10卷 / 03期

基金：

美国国家卫生研究院;

关键词：

NERVE GROWTH-FACTOR; SPINAL-CORD-INJURY; NEUROTROPHIC FACTOR BDNF; FACTOR GENE-THERAPY; PARKINSONS-DISEASE; HUNTINGTONS-DISEASE; ALZHEIMERS-DISEASE; VAL66MET POLYMORPHISM; DOPAMINERGIC-NEURONS; DIETARY RESTRICTION;

D O I：

10.1038/nrd3366

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 [微生物学]; 090105 [作物生产系统与生态工程];

摘要：

The growth factor brain-derived neurotrophic factor (BDNF) and its receptor tropomyosin-related kinase receptor type B (TRKB) are actively produced and trafficked in multiple regions in the adult brain, where they influence neuronal activity, function and survival throughout life. The diverse presence and activity of BDNF suggests a potential role for this molecule in the pathogenesis and treatment of both neurological and psychiatric disorders. This article reviews the current understanding and future directions in BDNF-related research in the central nervous system, with an emphasis on the possible therapeutic application of BDNF in modifying fundamental processes underlying neural disease.

引用

页码：209 / 219

页数：11

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