Synthesis of a caged glutamate for efficient one- and two-photon photorelease on living cells

被引：57

作者：

Fedoryak, OD ^{[1
]}

Sul, JY

Haydon, PG

Ellis-Davies, GCR

机构：

[1] Drexel Univ, Coll Med, Dept Pharmacol & Physiol, Philadelphia, PA 19102 USA

[2] Univ Penn, Med Ctr, Dept Neurosci, Philadelphia, PA 19104 USA

来源：

CHEMICAL COMMUNICATIONS | 2005年 / 29期

关键词：

D O I：

10.1039/b504922a

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

We have synthesized a biologically inert, photosensitive derivative of the major excitatory amino acid, L-glutamate (which we call MDNI-glu) that makes more efficient use of incident light than all other caged glutamates. Laser flash photolysis of MDNI-glu in acutely isolated hippocampal brain slices evoked a rapid increase in intracellular Ca2+ concentration in astrocytes.

引用

页码：3664 / 3666

页数：3

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