Increased serum levels of interleukin-6 in malnourished patients with colorectal cancer

被引:22
作者
Nakagoe, T
Tsuji, T
Sawai, T
Tanaka, K
Hidaka, S
Shibasaki, S
Nanashima, A
Ohbatake, M
Yamaguchi, H
Yasutake, T
Sugawara, K
Inokuchi, N
Kamihira, S
机构
[1] Nagasaki Univ, Sch Med, Dept Surg 1, Nagasaki 8528501, Japan
[2] Nagasaki Univ Hosp, Dept Lab Med, Nagasaki 8528501, Japan
关键词
D O I
10.1016/j.canlet.2003.09.008
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
Peri-operative serum levels of interleukin-6 (IL-6) were determined in 62 patients who underwent resection of colorectal cancer to clarify the relationship between nutritional status and IL-6 response. Patients were divided into two groups based on creatinine height index: malnourished group (n = 13) and normally nourished group (n = 49). The preoperative median serum level of IL-6 in the malnourished group was significantly higher than in the normally nourished group (P = 0.041). The postoperative median serum level of IL-6 in the malnourished group also tended to be higher. In conclusion, the peri-operative IL-6 response may be activated in malnourished colorectal cancer patients. (C) 2003 Elsevier Ireland Ltd. All rights reserved.
引用
收藏
页码:109 / 115
页数:7
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