Synthetic study on curacin A: A novel antimitotic agent from the cyanobacterium Lyngbya majuscula

被引：26

作者：

Onoda, T ^{[1
]}

Shirai, R ^{[1
]}

Koiso, Y ^{[1
]}

Iwasaki, S ^{[1
]}

机构：

[1] UNIV TOKYO,INST MOL & CELLULAR BIOSCI,BUNKYO KU,TOKYO 113,JAPAN

来源：

TETRAHEDRON | 1996年 / 52卷 / 46期

关键词：

D O I：

10.1016/0040-4020(96)00899-X

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Curacin A (1), a novel antimitotic agent, was synthesized in a highly stereo-controlled manner. The four stereoisomers of a partial structure at the thiazoline moiety, 2 were also synthesized to aid in elucidation of the absolute configurations of three chiral centers in curacin A. The effects on porcine brain tubulin assembly of several synthetic compounds related to curacin A were examined. Copyright (C) 1996 Elsevier Science Ltd

引用

页码：14543 / 14562

页数：20

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