Lentinus edodes heterogalactan: Antinociceptive and anti-inflammatory effects

被引：99

作者：

Carbonero, E. R. ^{[1
]}

Gracher, A. H. P. ^{[1
]}

Komura, D. L. ^{[1
]}

Marcon, R. ^{[2
]}

Freitas, C. S. ^{[3
]}

Baggio, C. H. ^{[3
]}

Santos, A. R. S. ^{[4
]}

Torri, G. ^{[5
]}

Gorin, P. A. J. ^{[1
]}

Iacomini, M. ^{[1
]}

机构：

[1] Univ Fed Parana, Dept Bioquim & Biol Mol, BR-81531980 Curitiba, Parana, Brazil

[2] Univ Fed Santa Catarina, Ctr Ciencias Biol, Dept Farmacol, BR-88049900 Florianopolis, SC, Brazil

[3] Univ Fed Parana, Dept Farmacol, BR-81531980 Curitiba, Parana, Brazil

[4] Univ Fed Santa Catarina, Ctr Ciencias Biol, Dept Ciencias Fisiol, BR-88040900 Florianopolis, SC, Brazil

[5] Ist Ric Chim Biochim & G Ronzoni, I-20133 Milan, Italy

来源：

FOOD CHEMISTRY | 2008年 / 111卷 / 03期

关键词：

Lentinus edodes; shiitake; basidiocarps; polysaccharide; fucomannogalactan; antinociceptive; anti-inflammatory effects;

D O I：

10.1016/j.foodchem.2008.04.015

中图分类号：

O69 [应用化学];

学科分类号：

081704 ;

摘要：

Cold aqueous extraction of basidiocarps (fruiting bodies) of the edible mushroom Lentinus edodes (shiitake) gave rise to a heteropolysaccharide, whose chemical structure, antinociceptive and anti-inflammatory properties were determined. Its chemical structure was based on monosaccharide composition, methylation analysis, and NMR spectroscopy (H-1, C-13, HSQC, HSQC-TOCSY, HSQC-NOESY, and coupled HMQC). It was found to be a fucomannogalactan with a main chain of (1 -> 6)-linked alpha-D-galactopyranosyl units, partially substituted at O-2 by single-unit beta-D-Manp or alpha-L-Fucp side chains. The polysaccharide produced a marked and dose-related effect when assessed against acetic acid-induced visceral nociception. Prevention of peritoneal capillary permeability and leukocyte infiltration caused by the acetic acid was similar in potency and effectiveness. (c) 2008 Elsevier Ltd. All rights reserved.

引用

页码：531 / 537

页数：7

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