Granulocyte transfusion therapy:: update on potential clinical applications

被引:18
作者
Hübel, K
Dale, DC
Liles, WC
机构
[1] Univ Washington, Dept Med, Seattle, WA 98195 USA
[2] Univ Cologne, Dept Internal Med 1, Cologne, Germany
关键词
D O I
10.1097/00062752-200105000-00006
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
The clinical usefulness of granulocyte transfusions for treatment or prevention of life-threatening bacterial and fungal infections remains controversial. Clinical benefit has long been limited by insufficient donor stimulation regimens and suboptimal leukapheresis techniques, Methodologic progress, in particular mobilization of neutrophils in healthy donors by administration of G-CSF, has significantly enhanced leukapheresis yields. A newly published study indicates that unrelated community donors can be effectively and safely used as an alternative to related family donors. Furthermore, several recent studies suggest that it may be possible to store granulocyte concentrates for 24 to 48 hours with adequate preservation of neutrophil function, This review summarizes the current role of granulocyte transfusion therapy in infectious diseases and highlights important recent advances. (C) 2001 Lippincott Williams & Wilkins, Inc.
引用
收藏
页码:161 / 164
页数:4
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