Triterpenoid saponins from Dipsacus asper and their activities in vitro

被引：15

作者：

Liu, Jing-Jing ^{[1
,2
]}

Wang, Xin-Luan ^{[3
]}

Guo, Bao-Lin ^{[1
,2
]}

Huang, Wen-Hua ^{[1
,2
]}

Xiao, Pei-Gen ^{[1
,2
]}

Huang, Chao-Qing ^{[1
,2
]}

Zheng, Li-Zhen ^{[3
]}

Zhang, Ge ^{[3
]}

Qin, Ling ^{[3
]}

Tu, Guang-Zhong ^{[4
]}

机构：

[1] Chinese Acad Med Sci, Inst Med Plants Dev, Key Lab Bioact Subst & Resources Utilizat Chinese, Minist Educ, Beijing 100193, Peoples R China

[2] Peking Union Med Coll, Beijing 100193, Peoples R China

[3] Chinese Univ Hong Kong, Dept Orthopaed & Traumatol, Musculoskeletal Res Lab, Hong Kong, Hong Kong, Peoples R China

[4] Beijing Inst Microchem, Beijing 100091, Peoples R China

来源：

JOURNAL OF ASIAN NATURAL PRODUCTS RESEARCH | 2011年 / 13卷 / 09期

关键词：

Dipsacus asper; triterpenoid saponin; anti-osteoporosis; UMR106; cell; cytotoxicity; CELL; BONE;

D O I：

10.1080/10286020.2011.598858

中图分类号：

Q94 [植物学];

学科分类号：

071001 [植物学];

摘要：

Two new triterpenoid saponins 1 and 2, along with six known saponins 3-8, were isolated from the roots of Dipsacus asper. The structures of new compounds were established as 3-O-beta-D-glucopyranosyl-(1 -> 4)-[alpha-L-rhamnopyranosyl-(1 -> 3)]-beta-D-glucopyranosyl-(1 -> 3)-alpha-L-rhamnopyranosyl-(1 -> 2)-alpha-L-arabinopyranosyl-hederagenin-28-O-beta-D-glucopyranoside (dipsacus saponin J, 1) and 3-O-alpha-L-arabinopyranosyl-hederagenin-28-O-beta-D-glucopyranosyl-(1 -> 6)-beta-D-glucopyranosyl-(1 -> 6)-beta-D-glucopyranoside (dipsacus saponin K, 2). The structures were determined by extensive analysis of their spectroscopic data. Compounds 6 and 7 could significantly stimulate UMR106 cell proliferation and increase alkaline phosphatase activities in UMR106 cell at the concentration of 4 mu M.

引用

页码：851 / 860

页数：10

共 18 条

[1]

Chinese Pharmacopoeia Committee, 2010, PHARM PEOPL REP CHIN, VI, P309

[2]

Calcification as an indicator of osteoinductive capacity of biomaterials in osteoblastic cell cultures [J].