Blood lead and zinc in pregnant women and their offspring in intrauterine growth retardation cases

被引:34
作者
Srivastava, S
Mehrotra, PK
Srivastava, SP
Tandon, I
Siddiqui, MKJ
机构
[1] Ind Toxicol Res Ctr, Lucknow 22601, Uttar Pradesh, India
[2] Univ Faizabad, Faizabad 224001, Uttar Pradesh, India
[3] Dr SPM Civil Hosp, Lucknow 226001, Uttar Pradesh, India
[4] King Georges Med Coll, Dept Obstet & Gynaecol, Lucknow 226001, Uttar Pradesh, India
关键词
D O I
10.1093/jat/25.6.461
中图分类号
O65 [分析化学];
学科分类号
070302 ; 081704 ;
摘要
As part of our program to investigate the possible role of environmental pollutants in the incidence of intrauterine-growth retardation (IUGR) in India, we determined the lead and zinc levels in mothers and neonatal blood, collected at parturition, in cases with normal and IUGR babies. Both maternal and cord blood lead levels were significantly higher in IUGR cases than in normal cases (p < 0.05). The mean level of zinc was also higher in maternal blood of IUGR cases. Significantly, the mean cord blood lead level was > 10 μg/dL, which is greater than Centers for Disease Control's intervention level, in 54% of newborns. A good correlation (r = 0.53, p < 0.01) between maternal and cord blood lead levels confirmed the transfer of lead from mother to the fetus. There was a weak but significant relationhsip between cord blood lead levels and birth weight of newborns (r = -0.22, p < 0.05). The study may serve as a pointer to the perils of in utero exposure to chemical contaminants and a call for measures by the public health authorities for a continuous bio-monitoring program to evaluate impact of environmental pollutants on women and children's health.
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页码:461 / 465
页数:5
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