Enantioselective Bronsted acid catalyzed addition reactions of methyleneaminopyrrolidine to imines

被引：46

作者：

Dixon, DJ

Tillman, AL

机构：

[1] Univ Manchester, Sch Chem, Manchester M13 9PL, Lancs, England

[2] Univ Cambridge, Chem Lab, Cambridge CB2 1EW, England

来源：

SYNLETT | 2005年 / 17期

关键词：

organocatalysis; hydrogen bond donor; imines; hydrazone; asymmetric synthesis;

D O I：

10.1055/s-2005-917098

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A new series of BINOL-derived multidentate Bronsted acid catalysts has been developed for the enantioselective addition of the d(1)-synthon, methyleneaminopyrrolidine, to N-Boc imines, yielding the versatile, protected alpha-aminohydrazone intermediates in moderate to good ee.

引用

页码：2635 / 2638

页数：4

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