Genome analysis of the platypus reveals unique signatures of evolution

被引：497

作者：

Warren, Wesley C. ^{[1
]}

Hillier, LaDeana W. ^{[1
]}

Graves, Jennifer A. Marshall ^{[2
]}

Birney, Ewan ^{[3
]}

Ponting, Chris P. ^{[4
]}

Grutzner, Frank ^{[5
]}

Belov, Katherine ^{[6
]}

Miller, Webb ^{[7
]}

Clarke, Laura ^{[8
]}

Chinwalla, Asif T. ^{[1
]}

Yang, Shiaw-Pyng ^{[1
]}

Heger, Andreas ^{[4
]}

Locke, Devin P. ^{[1
]}

Miethke, Pat ^{[2
]}

Waters, Paul D. ^{[2
]}

Veyrunes, Frederic ^{[2
,9
]}

Fulton, Lucinda ^{[1
]}

Fulton, Bob ^{[1
]}

Graves, Tina ^{[1
]}

Wallis, John ^{[1
]}

Puente, Xose S. ^{[10
]}

Lopez-Otin, Carlos ^{[10
]}

Ordonez, Gonzalo R. ^{[10
]}

Eichler, Evan E. ^{[11
]}

Chen, Lin ^{[11
]}

Cheng, Ze ^{[11
]}

Deakin, Janine E. ^{[2
]}

Alsop, Amber ^{[2
]}

Thompson, Katherine ^{[2
]}

Kirby, Patrick ^{[2
]}

Papenfuss, Anthony T. ^{[12
]}

Wakefield, Matthew J. ^{[12
]}

Olender, Tsviya ^{[13
]}

Lancet, Doron ^{[13
]}

Huttley, Gavin A. ^{[2
]}

Smit, Arian F. A. ^{[14
]}

Pask, Andrew ^{[15
]}

Temple-Smith, Peter ^{[15
,16
]}

Batzer, Mark A. ^{[17
]}

Walker, Jerilyn A. ^{[17
]}

Konkel, Miriam K. ^{[17
]}

Harris, Robert S. ^{[7
]}

Whittington, Camilla M. ^{[6
]}

Wong, Emily S. W. ^{[6
]}

Gemmell, Neil J. ^{[18
]}

Buschiazzo, Emmanuel ^{[18
]}

Jentzsch, Iris M. Vargas ^{[18
]}

Merkel, Angelika ^{[18
]}

Schmitz, Juergen ^{[19
]}

Zemann, Anja ^{[19
]}

机构：

[1] Washington Univ, Sch Med, Genome Sequencing Ctr, St Louis, MO 63108 USA

[2] Australian Natl Univ, John Curtin Sch Med Res, Canberra, ACT 0200, Australia

[3] EBI, EMBL, Cambridge CB10 1SD, England

[4] Univ Oxford, Dept Human Physiol Anat & Genet, MRC, Funct Genet Unit, Oxford OX1 3QX, England

[5] Univ Adelaide, Sch Mol & Biomed Sci, Discipline Genet, Adelaide, SA 5005, Australia

[6] Univ Sydney, Fac Vet Sci, Sydney, NSW 2006, Australia

[7] Penn State Univ, Ctr Comparat Genom & Bioinformat, University Pk, PA 16802 USA

[8] Wellcome Trust Sanger Inst, Cambridge CB10 1SA, England

[9] Univ Cambridge, Dept Vet Med, Cambridge CB3 0ES, England

[10] Univ Oviedo, Dept Bioquim & Biol Mol, Inst Univ Oncol, E-33006 Oviedo, Spain

[11] Univ Washington, Howard Hughes Med Inst, Dept Genome Sci, Seattle, WA 98195 USA

[12] Royal Melbourne Hosp, Walter & Eliza Hall Inst Med Res, Parkville, Vic 3050, Australia

[13] Weizmann Inst Sci, Dept Mol Genet, Crown Human Genome Ctr, IL-76100 Rehovot, Israel

[14] Inst Syst Biol, Seattle, WA 98103 USA

[15] Univ Melbourne, Dept Zool, CRC Innovat Dairy Prod, Parkville, Vic 3010, Australia

[16] Monash Inst Med Res, Clayton, Vic 3168, Australia

[17] Louisiana State Univ, Dept Biol Sci, Ctr Biomodular Multiscale Syst, Baton Rouge, LA 70803 USA

[18] Univ Canterbury, Sch Biol Sci, Christchurch 8140, New Zealand

[19] Univ Munster, Inst Expt Pathol, D-48149 Munster, Germany

[20] Cold Spring Harbor Lab, Howard Hughes Med Inst, Cold Spring Harbor, NY 11724 USA

[21] Monash Univ, Victorian Bioinformat Consortium, Clayton, Vic 3080, Australia

[22] W Virginia Univ, Dept Biol, Morgantown, WV 26505 USA

[23] Max Planck Inst Mol Genet, D-14195 Berlin, Germany

[24] Sperling Fdn, Eugene, OR 97405 USA

[25] NYU, Courant Inst, New York, NY 10012 USA

[26] Univ Newcastle, Sch Environm & Life Sci, Discipline Biol Sci, Newcastle, NSW 2308, Australia

[27] INRA, CNRS, UMR 6073, F-37380 Nouzilly, France

[28] RIKEN, CDB, Lab Pluripotent Cell Studies, Chuo Ku, Kobe, Hyogo 6500047, Japan

[29] Iowa State Univ, Dept Comp Sci, Ames, IA 50011 USA

[30] MIT, Broad Inst, Cambridge, MA 02139 USA

[31] Harvard Univ, Broad Inst, Cambridge, MA 02139 USA

来源：

NATURE | 2008年 / 453卷 / 7192期

基金：

英国惠康基金; 英国医学研究理事会; 奥地利科学基金会;

关键词：

D O I：

10.1038/nature06936

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

We present a draft genome sequence of the platypus, Ornithorhynchus anatinus. This monotreme exhibits a fascinating combination of reptilian and mammalian characters. For example, platypuses have a coat of fur adapted to an aquatic lifestyle; platypus females lactate, yet lay eggs; and males are equipped with venom similar to that of reptiles. Analysis of the first monotreme genome aligned these features with genetic innovations. We find that reptile and platypus venom proteins have been co- opted independently from the same gene families; milk protein genes are conserved despite platypuses laying eggs; and immune gene family expansions are directly related to platypus biology. Expansions of protein, non- protein- coding RNA and microRNA families, as well as repeat elements, are identified. Sequencing of this genome now provides a valuable resource for deep mammalian comparative analyses, as well as for monotreme biology and conservation.

引用

页码：175 / U1

页数：10

共 79 条

[41] Waves of genomic hitchhikers shed light on the evolution of gamebirds (Aves: Galliformes) [J].

Kriegs, Jan Ole ;

Matzke, Andreas ;

Churakov, Gennady ;

Kuritzin, Andrej ;

Mayr, Gerald ;

Brosius, Juergen ;

Schmitz, Juergen .

BMC EVOLUTIONARY BIOLOGY, 2007, 7 (1)

[42] Retroposed elements as archives for the evolutionary history of placental mammals [J].

Kriegs, JO ;

Churakov, G ;

Kiefmann, M ;

Jordan, U ;

Brosius, J ;

Schmitz, J .

PLOS BIOLOGY, 2006, 4 (04) :537-544

[43] Nonrandom distribution and frequencies of genomic and EST-derived microsatellite markers in rice, wheat, and barley [J].

La Rota, M ;

Kantety, RV ;

Yu, JK ;

Sorrells, ME .

BMC GENOMICS, 2005, 6 (1)

[44]

LESTER KS, 1987, SCANNING MICROSCOPY, V1, P401

[45] THE SMALL NUCLEOLAR RNAS [J].

MAXWELL, ES ;

FOURNIER, MJ .

ANNUAL REVIEW OF BIOCHEMISTRY, 1995, 64 :897-934

[46] Characterizing the chromosomes of the platypus (Ornithorhynchus anatinus) [J].

McMillan, Daniel ;

Miethke, Pat ;

Alsop, Amber E. ;

Rens, Willem ;

O'Brien, Patricia ;

Trifonov, Vladimir ;

Veyrunes, Frederic ;

Schatzkamer, Kyriena ;

Kremitzki, Colin L. ;

Graves, Tina ;

Warren, Wesley ;

Grutzner, Frank ;

Ferguson-Smith, Malcolm A. ;

Graves, Jennifer A. Marshall .

CHROMOSOME RESEARCH, 2007, 15 (08) :961-974

[47] Recombination drives the evolution of GC-content in the human genome [J].

Meunier, J ;

Duret, L .

MOLECULAR BIOLOGY AND EVOLUTION, 2004, 21 (06) :984-990

[48] Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences [J].

Mikkelsen, Tarjei S. ;

Wakefield, Matthew J. ;

Aken, Bronwen ;

Amemiya, Chris T. ;

Chang, Jean L. ;

Duke, Shannon ;

Garber, Manuel ;

Gentles, Andrew J. ;

Goodstadt, Leo ;

Heger, Andreas ;

Jurka, Jerzy ;

Kamal, Michael ;

Mauceli, Evan ;

Searle, Stephen M. J. ;

Sharpe, Ted ;

Baker, Michelle L. ;

Batzer, Mark A. ;

Benos, Panayiotis V. ;

Belov, Katherine ;

Clamp, Michele ;

Cook, April ;

Cuff, James ;

Das, Radhika ;

Davidow, Lance ;

Deakin, Janine E. ;

Fazzari, Melissa J. ;

Glass, Jacob L. ;

Grabherr, Manfred ;

Greally, John M. ;

Gu, Wanjun ;

Hore, Timothy A. ;

Huttley, Gavin A. ;

Kleber, Michael ;

Jirtle, Randy L. ;

Koina, Edda ;

Lee, Jeannie T. ;

Mahony, Shaun ;

Marra, Marco A. ;

Miller, Robert D. ;

Nicholls, Robert D. ;

Oda, Mayumi ;

Papenfuss, Anthony T. ;

Parra, Zuly E. ;

Pollock, David D. ;

Ray, David A. ;

Schein, Jacqueline E. ;

Speed, Terence P. ;

Thompson, Katherine ;

VandeBerg, John L. ;

Wade, Claire M. .

NATURE, 2007, 447 (7141) :167-U1

[49] The lipocalin sperm coating lizard epididymal secretory protein family:: mRNA structural analysis and sequential expression during the annual cycle of the lizard, Lacerta vivipara [J].

Morel, L ;

Dufaure, JP ;

Depeiges, A .

JOURNAL OF MOLECULAR ENDOCRINOLOGY, 2000, 24 (01) :127-133

[50]

MURCHISON EP, IN PRESS GENOME RES, DOI DOI 10.1101/GR.73056.107

← 1 2 3 4 5 6 7 8 →