Production and functions of IL-17 in microglia

被引：203

作者：

Kawanokuchi, Jun ^{[1
]}

Shimizu, Kouki ^{[1
]}

Nitta, Atsumi ^{[2
,3
]}

Yamada, Kiyofumi ^{[2
,3
]}

Mizuno, Tetsuya ^{[1
]}

Takeuchi, Hideyuki ^{[1
]}

Suzumura, Akio ^{[1
]}

机构：

[1] Nagoya Univ, Environm Med Res Inst, Dept Neuroimmunol, Chikusa Ku, Nagoya, Aichi 4648601, Japan

[2] Nagoya Univ, Grad Sch Med, Dept Neuropharmacol, Showa Ku, Nagoya, Aichi 4668560, Japan

[3] Nagoya Univ, Grad Sch Med, Hosp Pharm, Showa Ku, Nagoya, Aichi 4668560, Japan

来源：

JOURNAL OF NEUROIMMUNOLOGY | 2008年 / 194卷 / 1-2期

关键词：

cytokine; IL-17; EAE; MS; microglia;

D O I：

10.1016/j.jneuroim.2007.11.006

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Interleukin (IL)-17-producing helper T cells may play a pivotal role in the pathogenesis of multiple sclerosis. Here, we examined the effects of IL-17 on microglia, which are known to be critically involved in multiple sclerosis. Treatment with IL-17 upregulated the microglial production of IL-6. macrophage inflammatory protein-2, nitric oxide, adhesion molecules, and neurotrophic factors. We also found that IL-17 was produced by microglia in response to IL-23 or IL-1 beta. Because microglia produce IL-1 beta and IL-23, these cytokines may act in an autocrine manner to induce IL-17 expression in microglia, and thereby contribute to autoimmune diseases, such as MS, in the central nervous system. (C) 2007 Elsevier B.V. All rights reserved.

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页码：54 / 61

页数：8

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