Monitoring gene expression profile changes in ovarian carcinomas using cDNA microarray

被引：250

作者：

Wang, K

Gan, L

Jeffery, E

Gayle, M

Gown, AM

Skelly, M

Nelson, PS

Ng, WV

Schummer, M

Hood, L

Mulligan, J

机构：

[1] Chirosci R&D Inc, Bothell, WA 98021 USA

[2] Univ Washington, Dept Pathol, Seattle, WA 98195 USA

[3] Univ Washington, Dept Mol Biotechnol, Seattle, WA 98195 USA

来源：

GENE | 1999年 / 229卷 / 1-2期

关键词：

array; carcinogenesis; ovarian cancer; RT-PCR; tumor marker;

D O I：

10.1016/S0378-1119(99)00035-9

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

The development of cancer is the result of a series of molecular changes occurring in the cell. These events lead to changes in the expression level of numerous genes that result in different phenotypic characteristics of tumors. In this report we describe the assembly and utilization of a 5766 member cDNA microarray to study the differences in gene expression between normal and neoplastic human ovarian tissues. Several genes that may have biological relevance in the process of ovarian carcinogenesis have been identified through this approach. Analyzing the results of microarray hybridizations may provides new leads for tumor diagnosis and intervention. (C) 1999 Elsevier Science B.V. All rights reserved.

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页码：101 / 108

页数：8

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