Stabilizing Sodium Hypochlorite at High pH: Effects on Soft Tissue and Dentin

被引:35
作者
Jungbluth, Holger
Marending, Monika
De-Deus, Gustavo [2 ]
Sener, Beatrice
Zehnder, Matthias [1 ]
机构
[1] Univ Zurich, Ctr Dent Med, Dept Prevent Dent Periodontol & Cariol, Div Prevent Dent Periodontol & Cariol, CH-8032 Zurich, Switzerland
[2] Univ Veiga de Almeida, Rio De Janeiro, Brazil
关键词
Dentin; flexure strength; NaOCl; NaOH; tissue dissolution; ROOT-CANAL IRRIGANTS; DISSOLUTION CAPACITY; CALCIUM HYDROXIDE;
D O I
10.1016/j.joen.2011.02.019
中图分类号
R78 [口腔科学];
学科分类号
1003 ;
摘要
Introduction: When sodium hypochlorite solutions react with tissue, their pH drops and tissue sorption decreases. We studied whether stabilizing a NaOCl solution at a high pH would increase its soft-tissue dissolution capacity and effects on the dentin matrix compared with a standard NaOCl solution of the same concentration and similar initial pH. Methods: NaOCl solutions were prepared by mixing (1:1) a 10% stock solution with water (standard) or 2 mol/L NaOH (stabilized). Physiological saline and 1 nnol/L NaOH served as the controls. Chlorine content and alkaline capacity of NaOCl solutions were determined. Standardized porcine palatal soft-tissue specimens and human root dentin bars were exposed to test and control solutions. Weight loss percentage was assessed in the soft-tissue dissolution assay. Three-point bending tests were performed on the root dentin bars to determine the modulus of elasticity and flexural strength. Values between groups were compared using one-way analysis of variance with the Bonferroni correction for multiple testing (alpha < .05). Results: Both solutions contained 5% NaOCl. One milliliter of the standard and the stabilized solution consumed 4.0 mL and 13.7 mL of a 0.1-mol/L HCl solution before they reached a pH level of 7.5, respectively. The stabilized NaOCl dissolved significantly more soft tissue than the standard solution, and the pH remained high. It also caused a higher loss in elastic modulus and flexure strength (P < .05) than the control solutions, whereas the standard solution did not. Conclusions: NaOH-stabilized NaOCl solutions have a higher alkaline capacity and are thus more proteolytic than standard counterparts. (J Endod 2011;37:1593-696)
引用
收藏
页码:693 / 696
页数:4
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