p-Cresylsulfate and Indoxyl Sulfate Level at Different Stages of Chronic Kidney Disease

被引：116

作者：

Lin, Cheng-Jui ^{[1
,2
,3
]}

Chen, Han-Hsiang ^{[1
,2
]}

Pan, Chi-Feng ^{[4
,5
,6
]}

Chuang, Chih-Kuang ^{[7
]}

Wang, Tuen-Jen ^{[3
]}

Sun, Fang-Ju ^{[2
,8
]}

Wu, Chih-Jen ^{[1
,2
,9
]}

机构：

[1] Mackay Mem Hosp, Dept Internal Med, Div Nephrol, Taipei 104, Taiwan

[2] Mackay Med Nursing & Management Coll, Taipei, Taiwan

[3] Yuanpei Univ, Coll Wellbeing Sci & Technol, Dept Nursing, Hsinchu, Taiwan

[4] Mackay Mem Hosp, Dept Med Res, Div Genet & Metab, Taipei 104, Taiwan

[5] Fu Jen Catholic Univ, Coll Med, Taipei, Taiwan

[6] Natl Taipei Univ Technol, Inst Biotechnol, Taipei, Taiwan

[7] Mackay Mem Hosp, Dept Lab Med, Taipei 104, Taiwan

[8] Mackay Mem Hosp, Dept Med Res, Taipei 104, Taiwan

[9] Taipei Med Univ, Grad Inst Med Sci, Taipei, Taiwan

来源：

JOURNAL OF CLINICAL LABORATORY ANALYSIS | 2011年 / 25卷 / 03期

关键词：

protein-bound uremic toxin; p-cresylsulfate; indoxyl sulfate; chronic kidney disease; SERUM CONCENTRATIONS; UREMIC SOLUTES; CRESOL; HEMODIALYSIS; PROGRESSION; METABOLITE; MORTALITY; REMOVAL; TOXINS;

D O I：

10.1002/jcla.20456

中图分类号：

R446 [实验室诊断]; R-33 [实验医学、医学实验];

学科分类号：

1001 ;

摘要：

Indoxyl sulfate and p-cresylsulfate was associated with poor clinical outcome of uremia. We explored the relationship between the two toxins and renal function in chronic kidney disease (CKD) patients. This study enrolled 103 stable CKD patients (stage 3-5 and hemodialysis (HD) patients). Serum levels of indoxyl sulfate and p-cresylsulfate were measured using ultra performance liquid chromatography. General laboratory results and patient background were also checked. Patients with advanced CKD had higher serum indoxyl sulfate, p-cresylsulfate based on ANOVA test. There were significant correlation between indoxyl sulfate and p-cresylsulfate and serum creatinine after multivariate regression analysis (B=3.59, P<0.01; B=0.93, P=0.04, respectively). In addition, there was a positive correlation between indoxyl sulfate and p-cresylsulfate level (r=0.61, P<0.01). Indoxyl sulfate and p-cresylsulfate level increased gradually while renal function declined and reached the peak at the stage of HD. Serum indoxyl sulfate level was closely associated with p-cresylsulfate level in CKD patients. J. Clin. Lab. Anal. 25:191-197, 2011. (C) 2011 Wiley-Liss, Inc.

引用

页码：191 / 197

页数：7

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