Expression of vascular endothelial growth factor (VEGF)-C and VEGF-D in early gastric carcinoma: correlation with clinicopathological parameters

被引：127

作者：

Onogawa, S

Kitadai, Y

Amioka, T

Kodama, M

Cho, S

Kuroda, T

Ochiumi, T

Kimura, S

Kuwai, T

Tanaka, S

Chayama, K

机构：

[1] Hiroshima Univ, Grad Sch Biomed Sci, Dept Med & Mol Sci, Minami Ku, Hiroshima 7348551, Japan

[2] Hiroshima Univ Hosp, Dept Endoscopy, Minato Ku, Hiroshima 7348551, Japan

来源：

CANCER LETTERS | 2005年 / 226卷 / 01期

关键词：

gastric carcinoma; lymphangiogenesis; VEGF-C; VEGF-D;

D O I：

10.1016/j.canlet.2004.12.030

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 [肿瘤学];

摘要：

In this study, we investigated whether expression of vascular endothelial growth factor (VEGF)-C and/or VEGF-D correlates with clinicopathological features of human gastric carcinoma. We immunohistochemically examined the expression of VEGF-C and VEGF-D in 140 archival surgical specimens of submucosally invasive gastric carcinoma. Of these specimens, 32 (22.9%) and 12 (8.6%) showed intense VEGF-C and VEGF-D immunoreactivity in cancer cells, respectively. VEGF-C immunoreactivity was associated with histological type, lymphatic invasion, lymph node metastasis, and microvessel density. No association was identified between VEGF-D immunoreactivity and clinicopathological variables. These results suggest that VEGF-C is a dominant regulator of lymphangiogenesis in early-stage human gastric carcinoma. (c) 2005 Elsevier Ireland Ltd. All rights reserved.

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收藏

页码：85 / 90

页数：6

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