Value of ovarian stromal blood flow velocity measurement after pituitary suppression in the prediction of ovarian responsiveness and outcome of in vitro fertilization treatment

被引:100
作者
Engmann, L
Sladkevicius, P
Agrawal, R
Bekir, JS
Campbell, S
Tan, SL
机构
[1] London Womens Clin, London, England
[2] McGill Univ, Montreal, PQ H3A 2T5, Canada
关键词
color Doppler; ovarian stromal blood flow; predictive value; ovarian response; in vitro fertilization;
D O I
10.1016/S0015-0282(98)00406-3
中图分类号
R71 [妇产科学];
学科分类号
100211 ;
摘要
Objective: To evaluate whether ovarian stromal blood Bow velocity after pituitary suppression is predictive of ovarian response and the outcome of IVF treatment in patients with normal basal serum FSH levels and to compare the predictive value of this test with age, early follicular phase serum FSH level, E-2 level, and FSH:LH ratio. Design: Prospective observational study of women undergoing IVF treatment. Setting: A tertiary referral center for assisted reproduction. Patient(s): Eighty-eight women who received the long buserelin acetate treatment protocol. Intervention(s): Transvaginal color and pulsed Doppler measurement of the ovarian stromal peak systolic velocity (PSV) after pituitary suppression and measurement of the basal serum FSH level, E-2 level, and FSH:LH ratio. Main Outcome Measure(s): Number of mature oocytes retrieved and pregnancy rate. Result(s): Ovarian stromal PSV was the most important single independent predictor of ovarian response in patients with a normal basal serum FSH level, when compared with age, basal FSH level, E-2 level, or FSH:LH ratio. Patients in group 2 (PSV greater than or equal to 10 cm/s) had a significantly higher median number of mature oocytes retrieved (11 versus 5.5) and a higher clinical pregnancy rate (35.3% versus 11.3%) than patients in group 1 (PSV <10 cm/s), even after controlling for age. Conclusion(s): Ovarian stromal blood flow velocity, after pituitary suppression is confirmed, is predictive of ovarian responsiveness and the outcome of IVF treatment. (C) 1998 by American Society for Reproductive Medicine.
引用
收藏
页码:22 / 29
页数:8
相关论文
共 35 条
[1]   Influence of gonadotrophin-releasing hormone agonist total dose in the ovarian stimulation in the long down-regulation protocol for in-vitro fertilization [J].
Alvarez, C ;
Cremades, N ;
Blasco, N ;
Bernabeu, R .
HUMAN REPRODUCTION, 1997, 12 (11) :2366-2369
[2]   THE POOR-RESPONDER PATIENT IN AN IN-VITRO FERTILIZATION-EMBRYO TRANSFER PROGRAM [J].
BENRAFAEL, Z ;
FELDBERG, D .
JOURNAL OF ASSISTED REPRODUCTION AND GENETICS, 1993, 10 (02) :118-120
[3]   EXOGENOUS FOLLICLE-STIMULATING-HORMONE OVARIAN RESERVE TEST (EFORT) - A SIMPLE AND RELIABLE SCREENING-TEST FOR DETECTING POOR RESPONDERS IN IN-VITRO FERTILIZATION [J].
FANCHIN, R ;
DEZIEGLER, D ;
OLIVENNES, F ;
TAIEB, J ;
DZIK, A ;
FRYDMAN, R .
HUMAN REPRODUCTION, 1994, 9 (09) :1607-1611
[4]   Non-response to ovarian stimulation in normogonadotrophic, normogonadal women: A clinical sign of impending onset of ovarian failure pre-empting the rise in basal follicle stimulating hormone levels [J].
Farhi, J ;
Homburg, R ;
Ferber, A ;
Orvieto, R ;
BenRafael, Z .
HUMAN REPRODUCTION, 1997, 12 (02) :241-243
[5]   ANGIOGENESIS IN REPRODUCTIVE TISSUES [J].
FINDLAY, JK .
JOURNAL OF ENDOCRINOLOGY, 1986, 111 (03) :357-366
[6]   High-dose human menopausal gonadotropin stimulation in poor responders does not improve in vitro fertilization outcome [J].
Land, JA ;
Yarmolinskaya, MI ;
Dumoulin, JCM ;
Evers, JLH .
FERTILITY AND STERILITY, 1996, 65 (05) :961-965
[7]   PROGRESSIVE CHANGES IN LH AND FSH AND LH - FSH RATIO IN WOMEN THROUGHOUT REPRODUCTIVE LIFE [J].
LENTON, EA ;
SEXTON, L ;
LEE, S ;
COOKE, ID .
MATURITAS, 1988, 10 (01) :35-43
[8]   A CONTROLLED-STUDY COMPARING PATIENTS WITH AND WITHOUT POLYCYSTIC OVARIES UNDERGOING INVITRO FERTILIZATION [J].
MACDOUGALL, MJ ;
TAN, SL ;
BALEN, A ;
JACOBS, HS .
HUMAN REPRODUCTION, 1993, 8 (02) :233-237
[9]   HIGH-RATES OF PREGNANCY AFTER LONG-TERM DOWN-REGULATION OF WOMEN WITH SEVERE ENDOMETRIOSIS [J].
MARCUS, SF ;
EDWARDS, RG .
AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY, 1994, 171 (03) :812-817
[10]  
MEYER WR, 1990, OBSTET GYNECOL, V75, P795