Expression of aquaporin-1 in a long-term peritoneal dialysis patient with impaired transcellular water transport

被引：67

作者：

Goffin, E

Combet, S

Jamar, F

Cosyns, JP

Devuyst, O

机构：

[1] Univ Louvain, Sch Med, Div Nephrol, Brussels, Belgium

[2] Univ Louvain, Sch Med, Div Nucl Med, Brussels, Belgium

[3] Univ Louvain, Sch Med, Dept Pathol, Brussels, Belgium

来源：

AMERICAN JOURNAL OF KIDNEY DISEASES | 1999年 / 33卷 / 02期

关键词：

peritoneal dialysis; ultrafiltration failure; aquaporin-1; sodium sieving;

D O I：

10.1016/S0272-6386(99)70317-3

中图分类号：

R5 [内科学]; R69 [泌尿科学（泌尿生殖系疾病）];

学科分类号：

1002 ; 100201 ;

摘要：

Aquaporin-1 (AQP1) has been claimed to be the molecular counterpart of the transcellular pathway for free-water movement across the peritoneum during peritoneal dialysis, We report the case of a 67-year-old man, on peritoneal dialysis for 11 years, in whom ultrafiltration failure due to an abolition of the transcellular water transfer (documented by a loss of sodium sieving) was associated with an apparently normal expression of AQP1, We suggest that an alteration of AQP1 structure, rather than of its expression, accounts for this observation. (C) 1999 by the National Kidney Foundation, Inc.

引用

页码：383 / 388

页数：6

共 28 条

[1]

Akiba T, 1997, ADV PERIT D, V13, P3

[2]

CLARSSON O, 1996, AM J PHYSIOL, V271, pH2254

[3] Expression of aquaporins-1 and -2 during nephrogenesis and in autosomal dominant polycystic kidney disease [J].