Ursodeoxycholic acid treatment in patients with primary biliary cirrhosis - A Swedish multicentre, double-blind, randomized controlled study

被引:56
作者
Eriksson, LS
Olsson, R
Glauman, H
Prytz, H
Befrits, R
Ryden, BO
Einarsson, K
Lindgren, S
Wallerstedt, S
Weden, M
机构
[1] SAHLGRENS HOSP,DEPT MED,S-41345 GOTHENBURG,SWEDEN
[2] HUDDINGE HOSP,DEPT MED,S-14186 HUDDINGE,SWEDEN
[3] HUDDINGE HOSP,DEPT PATHOL,S-14186 HUDDINGE,SWEDEN
[4] OSTRA HOSP,DEPT MED,S-41685 GOTHENBURG,SWEDEN
[5] KAROLINSKA HOSP,DEPT MED,S-10401 STOCKHOLM,SWEDEN
[6] LINKOPING UNIV HOSP,DEPT MED,S-58185 LINKOPING,SWEDEN
[7] UNIV LUND HOSP,DEPT MED,S-22185 LUND,SWEDEN
[8] LUND UNIV,MALMO GEN HOSP,DEPT MED,S-21401 MALMO,SWEDEN
[9] SODERTALJE HOSP,DEPT MED,SODERTALJE,SWEDEN
关键词
bile acids; histology; liver function tests; primary biliary cirrhosis; ursodeoxycholic acid;
D O I
10.3109/00365529709000190
中图分类号
R57 [消化系及腹部疾病];
学科分类号
摘要
Background: Ursodeoxycholic acid (UDCA) has been shown to improve serum levels of liver enzymes and bilirubin in primary biliary cirrhosis (PBC). However, it is still uncertain whether UDCA treatment also improves symptoms, liver histology, and survival without liver transplantation. Methods: We randomized 116 patients with PBC to receive 0.5 g UDCA (n = 60) or placebo (n = 56) daily for 2 years. During the next 2 years, 80% of the UDCA-treated patients and 65% of the placebo-treated patients continued to rake UDCA. Results: UDCA improved serum enzyme values but not survival, symptoms, serum bilirubin levels, or liver histology. There was no significant difference in response between initially symptomatic and asymptomatic patients. Conclusions: UDCA in a dosage of 7.7 mg/kg body weight is of little benefit in PBC. This does not exclude the possibility that larger doses have beneficial effects.
引用
收藏
页码:179 / 186
页数:8
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