Identification of the inverted chromosome 16 using chromosome painting

被引：4

作者：

Rao, PN ^{[1
]}

Flejter, WL ^{[1
]}

Rahi, S ^{[1
]}

Li, H ^{[1
]}

Pettenati, MJ ^{[1
]}

机构：

[1] Wake Forest Univ, Sch Med, Dept Pediat, Med Genet Sect, Winston Salem, NC 27157 USA

来源：

BRITISH JOURNAL OF HAEMATOLOGY | 1999年 / 104卷 / 03期

关键词：

AML; AML-M4; inv(16); chromosome; 16; acute leukaemia;

D O I：

10.1046/j.1365-2141.1999.01228.x

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

The inverted chromosome 16 is commonly associated with acute myelomonocytic leukaemia (AML) M4 with bone marrow eosinophilia. Cytogenetic identification of the inverted chromosome 16 can be difficult. To help identify the inversion in bone marrow samples from patients referred for the diagnosis of AML-M4, we applied the molecular cytogenetic technique of chromosome painting using chromosome 16 p-arm paint. The results were concordant with standard chromosome analyses and clearly allowed fur the identification of a pericentric inversion within chromosome 10 even in poor-quality metaphase spreads.

引用

页码：618 / 620

页数：3

共 10 条

[1] AURTHER DC, 1983, BLOOD, V61, P994
[2] CLONING THE BREAKPOINT CLUSTER REGION OF THE INV(16) IN ACUTE NONLYMPHOCYTIC LEUKEMIA M4 EO
DAUWERSE, JG
WESSELS, JW
GILES, RH
WIEGANT, J
VANDERREIJDEN, BA
FUGAZZA, G
JUMELET, EA
SMIT, E
BAAS, F
RAAP, AK
HAGEMEIJER, A
BEVERSTOCK, GC
VANOMMEN, GJB
BREUNING, MH
[J]. HUMAN MOLECULAR GENETICS, 1993, 2 (10) : 1527 - 1534
[3] The abnormal eosinophils are part of the leukemic cell population in acute myelomonocytic leukemia with abnormal eosinophils (AML M4Eo) and carry the pericentric inversion 16: A combination of May-Grunwald-Giemsa staining and fluorescence in situ hybridization
Haferlach, T
Winkemann, M
Loffler, H
Schoch, R
Gassmann, W
Fonatsch, C
Schoch, C
Poetsch, M
WeberMatthiesen, K
Schlegelberger, B
[J]. BLOOD, 1996, 87 (06) : 2459 - 2463
[4] ASSOCIATION OF AN INVERSION OF CHROMOSOME-16 WITH ABNORMAL MARROW EOSINOPHILS IN ACUTE MYELOMONOCYTIC LEUKEMIA - A UNIQUE CYTOGENETIC CLINICOPATHOLOGICAL ASSOCIATION
LEBEAU, MM
LARSON, RA
BITTER, MA
VARDIMAN, JW
GOLOMB, HM
ROWLEY, JD
[J]. NEW ENGLAND JOURNAL OF MEDICINE, 1983, 309 (11) : 630 - 636
[5] FUSION BETWEEN TRANSCRIPTION FACTOR CBF-BETA/PEBP2-BETA AND A MYOSIN HEAVY-CHAIN IN ACUTE MYELOID-LEUKEMIA
LIU, P
TARLE, SA
HAJRA, A
CLAXTON, DF
MARLTON, P
FREEDMAN, M
SICILIANO, MJ
COLLINS, FS
[J]. SCIENCE, 1993, 261 (5124) : 1041 - 1044
[6] MOLECULAR CHARACTERIZATION OF 16P DELETIONS ASSOCIATED WITH INVERSION-16 DEFINES THE CRITICAL FUSION FOR LEUKEMOGENESIS
MARLTON, P
CLAXTON, DF
LIU, P
ESTEY, EH
BERAN, M
LEBEAU, M
TESTA, JR
COLLINS, FS
ROWLEY, JD
SICILIANO, MJ
[J]. BLOOD, 1995, 85 (03) : 772 - 779
[7] MARLTON P, 1995, LEUKEMIA, V9, P965
[8] Detection of 16 p deletions by FISH in patients with inv(16) or t(16;16) and acute myeloid leukemia (AML)
Martinet, D
Muhlematter, D
Leeman, M
Parlier, V
Hess, U
Gmur, J
Jotterand, M
[J]. LEUKEMIA, 1997, 11 (07) : 964 - 970
[9] HETEROGENEITY IN CBF-BETA/MYH11 FUSION MESSAGES ENCODED BY THE INV(16)(P13Q22) AND THE T(16-16)(P13-Q22) IN ACUTE MYELOGENOUS LEUKEMIA
SHURTLEFF, SA
MEYERS, S
HIEBERT, SW
RAIMONDI, SC
HEAD, DR
WILLMAN, CL
WOLMAN, S
SLOVAK, ML
CARROLL, AJ
BEHM, F
HULSHOF, MG
MOTRONI, TA
OKUDA, T
LIU, P
COLLINS, FS
DOWNING, JR
[J]. BLOOD, 1995, 85 (12) : 3695 - 3703
[10] DETECTION OF CBFB/MYH11 TRANSCRIPTS IN PATIENTS WITH INVERSION AND OTHER ABNORMALITIES OF CHROMOSOME-16 AT PRESENTATION AND REMISSION
TOBAL, K
JOHNSON, PRE
SAUNDERS, MJ
HARRISON, CJ
YIN, JAL
[J]. BRITISH JOURNAL OF HAEMATOLOGY, 1995, 91 (01) : 104 - 108

← 1 →