Isolation of alpha,alpha-difluoroketene silyl acetal and its application to asymmetric aldol reactions

被引：64

作者：

Iseki, K

Kuroki, Y

Asada, D

Kobayashi, Y

机构：

[1] MEC Laboratory, Daikin Industries, Ltd., Miyukigaoka, Tsukuba

来源：

TETRAHEDRON LETTERS | 1997年 / 38卷 / 08期

关键词：

D O I：

10.1016/S0040-4039(97)00044-0

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Salt-free alpha,alpha-difluoroketene silyl acetal 1 was prepared in pure form. Aldol reactions of 1 with aldehydes catalyzed by catalytic amounts of chiral Lewis acids 2 and 3 proceeded with excellent enantiomeric excess to give optically active alpha,alpha-difluoro-beta-hydroxy esters 4-11 (up to 98% ee). (C) 1997 Elsevier Science Ltd.

引用

页码：1447 / 1448

页数：2

共 15 条

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