Age-related decrease in responsiveness to L-DOPA is not due to changes in dopamine receptor mRNAs or G protein mRNAs

被引：2

作者：

Murata, M

Aihara, Y

Yamanouchi, H

Yamada, S

Kanazawa, I

机构：

[1] TOKYO METROPOLITAN GERIATR HOSP,DEPT NEUROL,TOKYO,JAPAN

[2] TOKYO METROPOLITAN INST GERONTOL,DEPT PATHOL,TOKYO,JAPAN

来源：

JOURNAL OF NEURAL TRANSMISSION | 1996年 / 103卷 / 03期

关键词：

age-related change; dopamine receptor; G protein; mRNA; L-DOPA responsiveness;

D O I：

10.1007/BF01271245

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

To clarify the cause of the age-related decrease in the responsiveness to L-DOPA seen in parkinsonian patients, we studied age-related changes in the mRNA levels of dopamine receptors (D1, D2) and of G proteins (Gs, Gi, Go) in 22 control human brains aged 50-105 years. Neither the mRNA levels of dopamine receptors or of the G proteins changed with age. Another factor in the receptor-G protein casccade, such as guanine nucleotide binding, may cause the age-related decrease in responsiveness.

引用

收藏

页码：343 / 348

页数：6

相关论文

共 28 条

[1] DOES AGING AGGRAVATE PARKINSONIAN DISABILITY [J].

BLIN, J ;

DUBOIS, B ;

BONNET, AM ;

VIDAILHET, M ;

BRANDABUR, M ;

AGID, Y .

JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY, 1991, 54 (09) :780-782

[2] REPEATED RESERPINE INCREASES STRIATAL DOPAMINE RECEPTOR AND GUANINE-NUCLEOTIDE BINDING-PROTEIN RNA [J].

BUTKERAIT, P ;

FRIEDMAN, E .

JOURNAL OF NEUROCHEMISTRY, 1993, 60 (02) :566-571

[3] THE OCCURRENCE OF MOTOR FLUCTUATIONS IN PARKINSONIAN-PATIENTS TREATED LONG-TERM WITH LEVODOPA - ROLE OF EARLY TREATMENT AND DISEASE PROGRESSION [J].

CARACENI, T ;

SCIGLIANO, G ;

MUSICCO, M .

NEUROLOGY, 1991, 41 (03) :380-384

[4] SINGLE-STEP METHOD OF RNA ISOLATION BY ACID GUANIDINIUM THIOCYANATE PHENOL CHLOROFORM EXTRACTION [J].

CHOMCZYNSKI, P ;

SACCHI, N .

ANALYTICAL BIOCHEMISTRY, 1987, 162 (01) :156-159

[5] ALTERATIONS IN LEUKOCYTE BETA-RECEPTOR AFFINITY WITH AGING - A POTENTIAL EXPLANATION FOR ALTERED BETA-ADRENERGIC SENSITIVITY IN THE ELDERLY [J].

FELDMAN, RD ;

LIMBIRD, LE ;

NADEAU, J ;

ROBERTSON, D ;

WOOD, AJJ .

NEW ENGLAND JOURNAL OF MEDICINE, 1984, 310 (13) :815-819

[6] POSTMORTEM STABILITY OF DOPAMINE D1 RECEPTOR MESSENGER-RNA AND D1 RECEPTORS [J].

GILMORE, JH ;

LAWLER, CP ;

EATON, AM ;

MAILMAN, RB .

MOLECULAR BRAIN RESEARCH, 1993, 18 (04) :290-296

[7] DOPAMINE-D2 RECEPTOR DENSITY REMAINS CONSTANT IN TREATED PARKINSONS-DISEASE [J].

GUTTMAN, M ;

SEEMAN, P ;

REYNOLDS, GP ;

RIEDERER, P ;

JELLINGER, K ;

TOURTELLOTTE, WW .

ANNALS OF NEUROLOGY, 1986, 19 (05) :487-492

[8] EFFECT OF AGING ON CONCENTRATIONS OF D2-RECEPTOR-CONTAINING NEURONS IN THE RAT STRIATUM [J].

HAN, Z ;

KUYATT, BL ;

KOCHMAN, KA ;

DESOUZA, EB ;

ROTH, GS .

BRAIN RESEARCH, 1989, 498 (02) :299-307

[9] MODULATION OF RAT STRIATAL MEMBRANE FLUIDITY - EFFECTS ON AGE-RELATED DIFFERENCES IN DOPAMINE RECEPTOR CONCENTRATIONS [J].

HENRY, JM ;

ROTH, GS .

LIFE SCIENCES, 1986, 39 (14) :1223-1229

[10] SPECIFIC REDUCTION OF CALCIUM-BINDING PROTEIN (28-KILODALTON CALBINDIN-D) GENE-EXPRESSION IN AGING AND NEURODEGENERATIVE DISEASES [J].

IACOPINO, AM ;

CHRISTAKOS, S .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1990, 87 (11) :4078-4082