A known risk factor for the development of coronary artery disease and subsequent myocardial infarction is hypercholesterolaemia. The widespread nature of this phenomenon in the western world has led to the development of agents which reduce serum cholesterol levels. One such class of agents, HMG-CoA reductase inhibitors (statins) are very effective in cholesterol reduction. Recently, clinical and experimental evidence has amassed suggesting that patients taking statins receive cardiovascular benefits that occur independent of cholesterol reduction. Experimental data suggest that statins may increase levels of nitric oxide (NO) in vivo. This review will address the 'cholesterol-independent' vasculoprotective and cardioprotective effects of statins in animal models. Upon completion, the reader will be familiar with the proposed cholesterol-independent pathways of statins and understand that the cholesterol-independent benefits may arise from enhanced production of NO.
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LOUISIANA STATE UNIV, MED CTR,DEPT PHYSIOL,1501 KINGS HIGHWAY,POB 33932, SHREVEPORT, LA 71130 USALOUISIANA STATE UNIV, MED CTR,DEPT PHYSIOL,1501 KINGS HIGHWAY,POB 33932, SHREVEPORT, LA 71130 USA
KUBES, P
SUZUKI, M
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LOUISIANA STATE UNIV, MED CTR,DEPT PHYSIOL,1501 KINGS HIGHWAY,POB 33932, SHREVEPORT, LA 71130 USALOUISIANA STATE UNIV, MED CTR,DEPT PHYSIOL,1501 KINGS HIGHWAY,POB 33932, SHREVEPORT, LA 71130 USA
SUZUKI, M
GRANGER, DN
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LOUISIANA STATE UNIV, MED CTR,DEPT PHYSIOL,1501 KINGS HIGHWAY,POB 33932, SHREVEPORT, LA 71130 USALOUISIANA STATE UNIV, MED CTR,DEPT PHYSIOL,1501 KINGS HIGHWAY,POB 33932, SHREVEPORT, LA 71130 USA
机构:Tufts Univ, Sch Med, St Elizabeths Med Ctr Boston, Div Cardiovasc Res, Boston, MA 02135 USA
Kureishi, Y
Luo, ZY
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机构:Tufts Univ, Sch Med, St Elizabeths Med Ctr Boston, Div Cardiovasc Res, Boston, MA 02135 USA
Luo, ZY
Shiojima, I
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机构:Tufts Univ, Sch Med, St Elizabeths Med Ctr Boston, Div Cardiovasc Res, Boston, MA 02135 USA
Shiojima, I
Bialik, A
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机构:Tufts Univ, Sch Med, St Elizabeths Med Ctr Boston, Div Cardiovasc Res, Boston, MA 02135 USA
Bialik, A
Fulton, D
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机构:Tufts Univ, Sch Med, St Elizabeths Med Ctr Boston, Div Cardiovasc Res, Boston, MA 02135 USA
Fulton, D
Lefer, DJ
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Lefer, DJ
Sessa, WC
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Sessa, WC
Walsh, K
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Tufts Univ, Sch Med, St Elizabeths Med Ctr Boston, Div Cardiovasc Res, Boston, MA 02135 USATufts Univ, Sch Med, St Elizabeths Med Ctr Boston, Div Cardiovasc Res, Boston, MA 02135 USA
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LOUISIANA STATE UNIV, MED CTR,DEPT PHYSIOL,1501 KINGS HIGHWAY,POB 33932, SHREVEPORT, LA 71130 USALOUISIANA STATE UNIV, MED CTR,DEPT PHYSIOL,1501 KINGS HIGHWAY,POB 33932, SHREVEPORT, LA 71130 USA
KUBES, P
SUZUKI, M
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LOUISIANA STATE UNIV, MED CTR,DEPT PHYSIOL,1501 KINGS HIGHWAY,POB 33932, SHREVEPORT, LA 71130 USALOUISIANA STATE UNIV, MED CTR,DEPT PHYSIOL,1501 KINGS HIGHWAY,POB 33932, SHREVEPORT, LA 71130 USA
SUZUKI, M
GRANGER, DN
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LOUISIANA STATE UNIV, MED CTR,DEPT PHYSIOL,1501 KINGS HIGHWAY,POB 33932, SHREVEPORT, LA 71130 USALOUISIANA STATE UNIV, MED CTR,DEPT PHYSIOL,1501 KINGS HIGHWAY,POB 33932, SHREVEPORT, LA 71130 USA
机构:Tufts Univ, Sch Med, St Elizabeths Med Ctr Boston, Div Cardiovasc Res, Boston, MA 02135 USA
Kureishi, Y
Luo, ZY
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h-index: 0
机构:Tufts Univ, Sch Med, St Elizabeths Med Ctr Boston, Div Cardiovasc Res, Boston, MA 02135 USA
Luo, ZY
Shiojima, I
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机构:Tufts Univ, Sch Med, St Elizabeths Med Ctr Boston, Div Cardiovasc Res, Boston, MA 02135 USA
Shiojima, I
Bialik, A
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机构:Tufts Univ, Sch Med, St Elizabeths Med Ctr Boston, Div Cardiovasc Res, Boston, MA 02135 USA
Bialik, A
Fulton, D
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机构:Tufts Univ, Sch Med, St Elizabeths Med Ctr Boston, Div Cardiovasc Res, Boston, MA 02135 USA
Fulton, D
Lefer, DJ
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机构:Tufts Univ, Sch Med, St Elizabeths Med Ctr Boston, Div Cardiovasc Res, Boston, MA 02135 USA
Lefer, DJ
Sessa, WC
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机构:Tufts Univ, Sch Med, St Elizabeths Med Ctr Boston, Div Cardiovasc Res, Boston, MA 02135 USA
Sessa, WC
Walsh, K
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h-index: 0
机构:
Tufts Univ, Sch Med, St Elizabeths Med Ctr Boston, Div Cardiovasc Res, Boston, MA 02135 USATufts Univ, Sch Med, St Elizabeths Med Ctr Boston, Div Cardiovasc Res, Boston, MA 02135 USA