A-substituted piperazines as constrained amino acids. Application to the synthesis of potent, non carboxylic acid inhibitors of farnesyltransferase

被引：56

作者：

Williams, TM

Ciccarone, TM

MacTough, SC

Bock, RL

Conner, MW

Davide, JP

Hamilton, K

Koblan, KS

Kohl, NE

Kral, AM

Mosser, SD

Omer, CA

Pompliano, DL

Rands, E

Schaber, MD

Shah, D

Wilson, FR

Gibbs, JB

Graham, SL

Hartman, GD

Oliff, AI

Smith, RL

机构：

[1] MERCK SHARP & DOHME LTD, DEPT CANC RES, RES LABS, West Point, PA 19486 USA

[2] MERCK SHARP & DOHME LTD, DEPT SAFETY ASSESSMENT, RES LABS, West Point, PA 19486 USA

[3] UNIV PENN, SCH MED, DEPT PHARMACOL, PHILADELPHIA, PA 19104 USA

来源：

JOURNAL OF MEDICINAL CHEMISTRY | 1996年 / 39卷 / 07期

关键词：

FARNESYL-PROTEIN TRANSFERASE; SELECTIVE-INHIBITION; RAS; P21RAS; PEPTIDOMIMETICS; BRAIN;

D O I：

10.1021/jm9508090

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

[No abstract available]

引用

页码：1345 / 1348

页数：4

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