Mechanisms of cancer metastasis to the bone

被引：269

作者：

Yin, JJ ^{[1
]}

Pollock, CB ^{[1
]}

Kelly, K ^{[1
]}

机构：

[1] NCI, Cell & Canc Biol Branch, NIH, Bethesda, MD 20892 USA

来源：

CELL RESEARCH | 2005年 / 15卷 / 01期

关键词：

cancer; bone metastases; osteolytic metastasis; osteoblastic metastasis;

D O I：

10.1038/sj.cr.7290266

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Some of the most common human cancers, including breast cancer, prostate cancer, and lung cancer, metastasize with avidity to bone. What is the basis for their preferential growth within the bone microenvironment? Bidirectional interactions between tumor cells and cells that make up bone result in a selective advantage for tumor growth and can lead to bone destruction or new bone matrix deposition. This review discusses our current understanding of the molecular components and mechanisms that are responsible for those interactions.

引用

页码：57 / 62

页数：6

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