Cell signaling events: a view from the matrix

被引:117
作者
Ramirez, F
Rifkin, DB
机构
[1] Cornell Univ, Weill Med Coll, Genet Lab, New York, NY 10021 USA
[2] NYU, Sch Med, Dept Cell Biol, New York, NY 10016 USA
[3] NYU, Sch Med, Dept Med, New York, NY 10016 USA
[4] Cornell Univ, Weill Med Coll, Organogenesis Hosp Special Surg, New York, NY 10021 USA
关键词
cell signaling events; extracellular matrix;
D O I
10.1016/S0945-053X(03)00002-7
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Cellular activities are primarily initiated, modulated and sustained by multifunctional molecules (cytokines and growth factors) that are secreted into the extracellular space and that signal through membrane-bound, high-affinity receptors. In contrast to the fairly well understood mechanisms that mediate the specificity of signal transduction within the confined and compartmentalized environment of the cell, significantly less is known about the mechanisms that regulate the availability of signaling molecules in the extracellular milieu. Recent findings have implicated the participation of extracellular protein macroaggregates in signaling events controlling patterning and morphogenesis. The results suggest a functional coupling between the tissue-specific organization of collagenous and elastic macroaggregates and their ability to perform instructive as well as structural functions. These observations open the way to a novel understanding in these poorly understood and critically important areas of cell and developmental biology. (C) 2003 Elsevier Science B.V./International Society of Matrix Biology. All rights reserved.
引用
收藏
页码:101 / 107
页数:7
相关论文
共 40 条
[1]   Chordin-like CR domains and the regulation of evolutionarily conserved extracellular signaling systems [J].
Abreu, JG ;
Coffinier, C ;
Larraín, J ;
Oelgeschläger, M ;
De Robertis, EM .
GENE, 2002, 287 (1-2) :39-47
[2]   The latent-TGFβ-binding-protein-1 (LTBP-1) is expressed in the organizer and regulates nodal and activin signaling [J].
Altmann, CR ;
Chang, CB ;
Muñoz-Sanjuán, I ;
Bell, E ;
Heke, M ;
Rifkin, DB ;
Brivanlou, AH .
DEVELOPMENTAL BIOLOGY, 2002, 248 (01) :118-127
[3]   Making sense of latent TGFβ activation [J].
Annes, JP ;
Munger, JS ;
Rifkin, DB .
JOURNAL OF CELL SCIENCE, 2003, 116 (02) :217-224
[4]   Regulation of limb patterning by extracellular microfibrils [J].
Arteaga-Solis, E ;
Gayraud, B ;
Lee, SY ;
Shum, L ;
Sakai, L ;
Ramirez, F .
JOURNAL OF CELL BIOLOGY, 2001, 154 (02) :275-281
[5]   Collagen II is essential for the removal of the notochord and the formation of intervertebral discs [J].
Aszódi, A ;
Chan, D ;
Hunziker, E ;
Bateman, JF ;
Fässler, R .
JOURNAL OF CELL BIOLOGY, 1998, 143 (05) :1399-1412
[6]   Structure and biological activity of the extracellular matrix [J].
Aumailley, M ;
Gayraud, B .
JOURNAL OF MOLECULAR MEDICINE-JMM, 1998, 76 (3-4) :253-265
[7]  
Baeg GH, 2001, DEVELOPMENT, V128, P87
[8]   POTENTIAL MECHANISMS REGULATING THE EXTRACELLULAR ACTIVITIES OF BASIC FIBROBLAST GROWTH-FACTOR (FGF-S) [J].
BAIRD, A .
MOLECULAR REPRODUCTION AND DEVELOPMENT, 1994, 39 (01) :43-48
[9]   Functions of cell surface heparan sulfate proteoglycans [J].
Bernfield, M ;
Götte, M ;
Park, PW ;
Reizes, O ;
Fitzgerald, ML ;
Lincecum, J ;
Zako, M .
ANNUAL REVIEW OF BIOCHEMISTRY, 1999, 68 :729-777
[10]   THE EXTRACELLULAR REGULATION OF GROWTH-FACTOR ACTION [J].
FLAUMENHAFT, R ;
RIFKIN, DB .
MOLECULAR BIOLOGY OF THE CELL, 1992, 3 (10) :1057-1065