The dynamic organization of postsynaptic proteins: translocating molecules regulate synaptic function
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作者:
Inoue, A
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Tokyo Med & Dent Univ, Sch Med, Dept Anat & Cell Biol, Bunkyo Ku, Tokyo 1138519, JapanTokyo Med & Dent Univ, Sch Med, Dept Anat & Cell Biol, Bunkyo Ku, Tokyo 1138519, Japan
Inoue, A
[1
]
Okabe, S
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Tokyo Med & Dent Univ, Sch Med, Dept Anat & Cell Biol, Bunkyo Ku, Tokyo 1138519, JapanTokyo Med & Dent Univ, Sch Med, Dept Anat & Cell Biol, Bunkyo Ku, Tokyo 1138519, Japan
Okabe, S
[1
]
机构:
[1] Tokyo Med & Dent Univ, Sch Med, Dept Anat & Cell Biol, Bunkyo Ku, Tokyo 1138519, Japan
Physiological roles for postsynaptic molecules in synaptogenesis and plasticity are under intense investigation. Recent imaging experiments, including GFP-based and single-particle tracking strategies, reveal rapid movement of synaptic components to and from the postsynaptic sites. Furthermore, specific patterns of neuronal activity and/or activation of specific transmitter receptors trigger selective translocation of postsynaptic components. These emerging dynamic properties of synaptic specializations add another layer of complexity to the signaling mechanisms of CNS synapses.
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Technion Israel Inst Technol, Rappaport Family Inst Res Med Sci, IL-31096 Haifa, IsraelTechnion Israel Inst Technol, Rappaport Family Inst Res Med Sci, IL-31096 Haifa, Israel
Bresler, T
Ramati, Y
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机构:Technion Israel Inst Technol, Rappaport Family Inst Res Med Sci, IL-31096 Haifa, Israel
Ramati, Y
Zamorano, PL
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机构:Technion Israel Inst Technol, Rappaport Family Inst Res Med Sci, IL-31096 Haifa, Israel
Zamorano, PL
Zhai, R
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机构:Technion Israel Inst Technol, Rappaport Family Inst Res Med Sci, IL-31096 Haifa, Israel
Zhai, R
Garner, CC
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机构:Technion Israel Inst Technol, Rappaport Family Inst Res Med Sci, IL-31096 Haifa, Israel
Garner, CC
Ziv, NE
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机构:Technion Israel Inst Technol, Rappaport Family Inst Res Med Sci, IL-31096 Haifa, Israel
机构:
Technion Israel Inst Technol, Rappaport Family Inst Res Med Sci, IL-31096 Haifa, IsraelTechnion Israel Inst Technol, Rappaport Family Inst Res Med Sci, IL-31096 Haifa, Israel
Bresler, T
Ramati, Y
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机构:Technion Israel Inst Technol, Rappaport Family Inst Res Med Sci, IL-31096 Haifa, Israel
Ramati, Y
Zamorano, PL
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机构:Technion Israel Inst Technol, Rappaport Family Inst Res Med Sci, IL-31096 Haifa, Israel
Zamorano, PL
Zhai, R
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机构:Technion Israel Inst Technol, Rappaport Family Inst Res Med Sci, IL-31096 Haifa, Israel
Zhai, R
Garner, CC
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机构:Technion Israel Inst Technol, Rappaport Family Inst Res Med Sci, IL-31096 Haifa, Israel
Garner, CC
Ziv, NE
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机构:Technion Israel Inst Technol, Rappaport Family Inst Res Med Sci, IL-31096 Haifa, Israel