The dynamic organization of postsynaptic proteins: translocating molecules regulate synaptic function

被引:44
作者
Inoue, A [1 ]
Okabe, S [1 ]
机构
[1] Tokyo Med & Dent Univ, Sch Med, Dept Anat & Cell Biol, Bunkyo Ku, Tokyo 1138519, Japan
基金
日本科学技术振兴机构;
关键词
D O I
10.1016/S0959-4388(03)00077-1
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
Physiological roles for postsynaptic molecules in synaptogenesis and plasticity are under intense investigation. Recent imaging experiments, including GFP-based and single-particle tracking strategies, reveal rapid movement of synaptic components to and from the postsynaptic sites. Furthermore, specific patterns of neuronal activity and/or activation of specific transmitter receptors trigger selective translocation of postsynaptic components. These emerging dynamic properties of synaptic specializations add another layer of complexity to the signaling mechanisms of CNS synapses.
引用
收藏
页码:332 / 340
页数:9
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