Transcription of Inflammatory Genes: Long Noncoding RNA and Beyond

被引：31

作者：

Carpenter, Susan ^{[1
,2
]}

Fitzgerald, Katherine A. ^{[1
]}

机构：

[1] Univ Massachusetts, Sch Med, Dept Med, Program Innate Immun,Div Infect Dis & Immunol, Worcester, MA 01605 USA

[2] Univ Calif San Francisco, Dept Microbiol & Immunol, Ctr Diabet, San Francisco, CA 94143 USA

来源：

JOURNAL OF INTERFERON AND CYTOKINE RESEARCH | 2015年 / 35卷 / 02期

关键词：

INNATE IMMUNE-SYSTEM; RECOGNITION RECEPTORS; PATHOGEN RECOGNITION; SIGNALING PATHWAYS; REGULATORY CIRCUIT; DNA METHYLATION; HIGH-THROUGHPUT; RESPONSE GENES; C/EBP-DELTA; KAPPA-B;

D O I：

10.1089/jir.2014.0120

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The innate immune system must coordinate elaborate signaling pathways to turn on expression of hundreds of genes to provide protection against pathogens and resolve acute inflammation. Multiple genes within distinct functional categories are coordinately and temporally regulated by transcriptional on and off switches in response to distinct external stimuli. Three classes of transcription factors act together with transcriptional coregulators and chromatin-modifying complexes to control these programs. In addition, newer studies implicate long noncoding RNA (lncRNA) as additional regulators of these responses. LncRNAs promote, fine-tune, and restrain the inflammatory program. In this study, we provide an overview of gene regulation and the emerging importance of lncRNAs in the immune system.

引用

页码：79 / 88

页数：10

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