5-Endo-dig electrophilic cyclization of 1,4-disubstituted but-3-yn-1-ones:: Regiocontrolled synthesis of 2,5-disubstituted 3-bromo- and 3-iodofurans

被引：167

作者：

Sniady, A

Wheeler, KA

Dembinski, R

机构：

[1] Oakland Univ, Dept Chem, Rochester, MI 48309 USA

[2] Delaware State Univ, Dept Chem, Sagamiko, Kanagawa 19901, Japan

来源：

ORGANIC LETTERS | 2005年 / 7卷 / 09期

关键词：

D O I：

10.1021/ol050372i

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

5-Endo-digelectrophilic cyclization of 1,4-diaryl but-3-yn-1-ones with N-bromosuccinimide or N-iodosuccinimide/acetone and iodine monochloride/ CH2CL2, at room temperature, in the absence of base, provides 3-halo-2,5-diarylfurans with excellent regiocontrol and high yields (81-94%).

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页码：1769 / 1772

页数：4

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