Clinical trials of pharmacotherapy for spinal cord injury

被引：16

作者：

Geisler, FH ^{[1
]}

机构：

[1] Chicago Inst Neurosurg & Neurores, Chicago, IL 60614 USA

来源：

SPHINGOLIPIDS AS SIGNALING MODULATORS IN THE NERVOUS SYSTEM | 1998年 / 845卷

关键词：

D O I：

10.1111/j.1749-6632.1998.tb09689.x

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Spinal cord injury remains with limited natural recovery and only a few general ineffective treatment options. Recent publications have reported enhanced neurologic recovery with the use of methylprednisolone and GM-1 ganglioside. The results of the Maryland GM-1 Ganglioside Study reported a significant drug effect with respect to the fraction of patients that had a change of two or more Frankel grades from entrance into the study to 1-year follow-up. This study formed the basis for the currently ongoing larger placebo-controlled multicentered study using Sygen(R) GM-1 following acute spinal cord injury. This study has entered 797 patients and is expected to present results in early 1998.

引用

页码：374 / 381

页数：8

共 48 条

[1]

American Spinal Injury Association, 1992, INT STAND NEUR FUNCT

[2]

Baker S.B., 1992, The injury fact book

[3] FUNCTIONAL RECOVERY AFTER DECOMPRESSIVE SPINE OPERATION FOR CERVICAL-SPINE FRACTURES [J].

BENZEL, EC ;

LARSON, SJ .

NEUROSURGERY, 1987, 20 (05) :742-746

[4]

Bracken M B, 1991, J Neurotrauma, V8 Suppl 1, pS47

[5]

BRACKEN MB, 1984, JAMA-J AM MED ASSOC, V251, P45, DOI 10.1001/jama.1984.03340250025015

[6] METHYLPREDNISOLONE AND NEUROLOGICAL FUNCTION 1 YEAR AFTER SPINAL-CORD INJURY - RESULTS OF THE NATIONAL ACUTE SPINAL-CORD INJURY STUDY [J].

BRACKEN, MB ;

SHEPARD, MJ ;

HELLENBRAND, KG ;

COLLINS, WF ;

LEO, LS ;

FREEMAN, DF ;

WAGNER, FC ;

FLAMM, ES ;

EISENBERG, HM ;

GOODMAN, JH ;

PEROT, PL ;

GREEN, BA ;

GROSSMAN, RG ;

MEAGHER, JN ;

YOUNG, W ;

FISCHER, B ;

CLIFTON, GL ;

HUNT, WE ;

RIFKINSON, N .

JOURNAL OF NEUROSURGERY, 1985, 63 (05) :704-713

[7] INCIDENCE OF ACUTE TRAUMATIC HOSPITALIZED SPINAL-CORD INJURY IN THE UNITED-STATES, 1970-1977 [J].

BRACKEN, MB ;

FREEMAN, DH ;

HELLENBRAND, K .

AMERICAN JOURNAL OF EPIDEMIOLOGY, 1981, 113 (06) :615-622

[8] EFFECTS OF TIMING OF METHYLPREDNISOLONE OR NALOXONE ADMINISTRATION ON RECOVERY OF SEGMENTAL AND LONG-TRACT NEUROLOGICAL FUNCTION IN NASCIS-2 [J].

BRACKEN, MB ;

HOLFORD, TR .

JOURNAL OF NEUROSURGERY, 1993, 79 (04) :500-507

[9] A RANDOMIZED, CONTROLLED TRIAL OF METHYLPREDNISOLONE OR NALOXONE IN THE TREATMENT OF ACUTE SPINAL-CORD INJURY - RESULTS OF THE 2ND NATIONAL ACUTE SPINAL-CORD INJURY STUDY [J].

BRACKEN, MB ;

SHEPARD, MJ ;

COLLINS, WF ;

HOLFORD, TR ;

YOUNG, W ;

BASKIN, DS ;

EISENBERG, HM ;

FLAMM, E ;

LEOSUMMERS, L ;

MAROON, J ;

MARSHALL, LF ;

PEROT, PL ;

PIEPMEIER, J ;

SONNTAG, VKH ;

WAGNER, FC ;

WILBERGER, JE ;

WINN, HR .

NEW ENGLAND JOURNAL OF MEDICINE, 1990, 322 (20) :1405-1411

[10] METHYLPREDNISOLONE OR NALOXONE TREATMENT AFTER ACUTE SPINAL-CORD INJURY - 1-YEAR FOLLOW-UP DATA - RESULTS OF THE 2ND NATIONAL ACUTE SPINAL-CORD INJURY STUDY [J].

BRACKEN, MB ;

SHEPARD, MJ ;

COLLINS, WF ;

HOLFORD, TR ;

BASKIN, DS ;

EISENBERG, HM ;

FLAMM, E ;

LEOSUMMERS, L ;

MAROON, JC ;

MARSHALL, LF ;

PEROT, PL ;

PIEPMEIER, J ;

SONNTAG, VKH ;

WAGNER, FC ;

WILBERGER, JL ;

WINN, HR ;

YOUNG, W .

JOURNAL OF NEUROSURGERY, 1992, 76 (01) :23-31

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