Wake-promoting actions of medial basal forebrain β2 receptor stimulation

被引：12

作者：

Berridge, CW ^{[1
]}

Stellick, RL ^{[1
]}

Schmeichel, BE ^{[1
]}

机构：

[1] Univ Wisconsin, Dept Psychol, Madison, WI 53706 USA

来源：

BEHAVIORAL NEUROSCIENCE | 2005年 / 119卷 / 03期

关键词：

arousal; locus coeruleus; norepinephrine; medial septal area; medial preoptic area;

D O I：

10.1037/0735-7044.119.3.743

中图分类号：

B84 [心理学]; C [社会科学总论]; Q98 [人类学];

学科分类号：

03 ; 0303 ; 030303 ; 04 ; 0402 ;

摘要：

The locus coeruleus-noradrenergic system exerts an activating influence on forebrain neuronal and behavioral activity states, in part, through the actions of noradrenergic beta receptors located within the medial septal (MS) and medial preoptic (MPOA) areas. The current study examined the extent to which beta(2) receptors located within these medial basal forebrain regions modulate behavioral state. In this study, the sleep-wake effects of microinfusion of the beta(2) agonist, clenbuterol, into the MS and MPOA were examined. Clenbuterol infusion into both MS and MPOA elicited a dose-dependent increase in time spent awake. These observations indicate that medial basal forebrain beta(2) receptors participate in the noradrenergic-dependent modulation of behavioral state.

引用

页码：743 / 751

页数：9

共 49 条

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