Involvement of a single-stranded DNA binding protein, ssCRE-BP/Pur alpha, in morphine dependence

被引：25

作者：

Osugi, T ^{[1
]}

Ding, Y ^{[1
]}

Tanaka, H ^{[1
]}

Kuo, CH ^{[1
]}

Do, E ^{[1
]}

Irie, Y ^{[1
]}

Miki, N ^{[1
]}

机构：

[1] OSAKA UNIV,SCH MED,DEPT PHARMACOL 1,SUITA,OSAKA 565,JAPAN

来源：

FEBS LETTERS | 1996年 / 391卷 / 1-2期

关键词：

single-stranded cAMP response element; morphine dependence; DNA binding protein; Pur alpha; mouse cerebellum;

D O I：

10.1016/0014-5793(96)00696-5

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

We have purified a nuclear protein from mouse cerebella that binds to single-stranded oligo-DNA of cAMP response element and is modulated by morphine treatment. Isolation of the cDNA clone showed that the nuclear protein (ssCRE-BP) was identical to Pur alpha, a DNA binding protein for single-stranded purine-rich sequences that was originally isolated as a replication factor. ssCRE-BP/Pur alpha and mRNA were abundant in the brain. The levels of ssCRE-BP/Pur alpha and the transcript were not changed by chronic morphine treatment, however, the levels of an activator of ssCRE-BP/Pur alpha which is necessary for the DNA binding, may be modulated by the treatment.

引用

页码：11 / 16

页数：6

共 24 条

[1] TIME-DOSE RELATIONSHIPS FOR LOCOMOTOR ACTIVITY EFFECTS OF MORPHINE AFTER ACUTE OR REPEATED TREATMENT [J].

BABBINI, M ;

DAVIS, WM .

BRITISH JOURNAL OF PHARMACOLOGY, 1972, 46 (02) :213-&

[2] THE HELA PUR FACTOR BINDS SINGLE-STRANDED-DNA AT A SPECIFIC ELEMENT CONSERVED IN GENE FLANKING REGIONS AND ORIGINS OF DNA-REPLICATION [J].

BERGEMANN, AD ;

JOHNSON, EM .

MOLECULAR AND CELLULAR BIOLOGY, 1992, 12 (03) :1257-1265

[3] SEQUENCE OF CDNA COMPRISING THE HUMAN PUR GENE AND SEQUENCE-SPECIFIC SINGLE-STRANDED-DNA-BINDING PROPERTIES OF THE ENCODED PROTEIN [J].

BERGEMANN, AD ;

MA, ZW ;

JOHNSON, EM .

MOLECULAR AND CELLULAR BIOLOGY, 1992, 12 (12) :5673-5682

[4] LOCOMOTOR-ACTIVITY IN MORPHINE-DEPENDENT AND POST-DEPENDENT RATS [J].

BRADY, LS ;

HOLTZMAN, SG .

PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR, 1981, 14 (03) :361-370

[5] MORPHINE ACTIVATION OF C-FOS EXPRESSION IN RAT-BRAIN [J].

CHANG, SL ;

SQUINTO, SP ;

HARLAN, RE .

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 1988, 157 (02) :698-704

[6] COOPERATIVE ACTION OF CELLULAR PROTEINS YB-1 AND PUR-ALPHA WITH THE TUMOR-ANTIGEN OF THE HUMAN JC POLYOMAVIRUS DETERMINES THEIR INTERACTION WITH THE VIRAL LYTIC CONTROL ELEMENT [J].

CHEN, NN ;

CHANG, CF ;

GALLIA, GL ;

KERR, DA ;

JOHNSON, EM ;

KRACHMAROV, CP ;

BARR, SM ;

FRISQUE, RJ ;

BOLLAG, B ;

KHALILI, K .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1995, 92 (04) :1087-1091

[7] SINGLE-STEP METHOD OF RNA ISOLATION BY ACID GUANIDINIUM THIOCYANATE PHENOL CHLOROFORM EXTRACTION [J].

CHOMCZYNSKI, P ;

SACCHI, N .

ANALYTICAL BIOCHEMISTRY, 1987, 162 (01) :156-159

[8] DUAL ROLE OF TFIIH IN DNA EXCISION-REPAIR AND IN TRANSCRIPTION BY RNA-POLYMERASE-II [J].

DRAPKIN, R ;

REARDON, JT ;

ANSARI, A ;

HUANG, JC ;

ZAWEL, L ;

AHN, KJ ;

SANCAR, A ;

REINBERG, D .

NATURE, 1994, 368 (6473) :769-772

[9] POSSIBLE MECHANISM OF ACTION OF MORPHINE ON BRAIN [J].

EIDELBERG, E ;

SCHWARTZ, AS .

NATURE, 1970, 225 (5238) :1152-+

[10] AMPHETAMINE AND COCAINE INDUCE DRUG-SPECIFIC ACTIVATION OF THE C-FOS GENE IN STRIOSOME MATRIX COMPARTMENTS AND LIMBIC SUBDIVISIONS OF THE STRIATUM [J].

GRAYBIEL, AM ;

MORATALLA, R ;

ROBERTSON, HA .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1990, 87 (17) :6912-6916

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