Physiological and molecular basis of thyroid hormone action

被引:1504
作者
Yen, PM [1 ]
机构
[1] NIDDK, Mol REgulat & Neuroendocrinol Sect, Clin Endocrinol Branch, NIH, Bethesda, MD 20892 USA
关键词
D O I
10.1152/physrev.2001.81.3.1097
中图分类号
Q4 [生理学];
学科分类号
071003 ;
摘要
Thyroid hormones (THs) play critical roles in the differentiation, growth, metabolism, and physiological function of virtually all tissues. TH binds to receptors that are ligand-regulatable transcription factors belonging to the nuclear hormone receptor superfamily. Tremendous progress has been made recently in our understanding of the molecular mechanisms that underlie TH action. In this review, we present the major advances in our knowledge of the molecular mechanisms of TH action and their implications for TH action in specific tissues, resistance to thyroid hormone syndrome, and genetically engineered mouse models.
引用
收藏
页码:1097 / 1142
页数:46
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